PKR (Thr446) Antibody, ALEXA FLUOR 555

Catalog number:	bs-3335R-A555 Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	PKR (Thr446) Antibody, ALEXA FLUOR 555
Quantity:	0.1ml
Related search:	alexa thr kinase protein phosphorylation conjugated synonyms eifak ifihcp

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Long name:	ALEXA FLUOR 555 Conjugated, PKR (Thr446) Polyclonal Antibody
Also known as:	Anti-PKR Thr446 PAb ALEXA FLUOR 555
Category:	Conjugated Primary Antibodies
Conjugated with:	555, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	PKR Thr446
Specificity:	This is a highly specific antibody against PKR Thr446
Modification:	Phosphorylation
Modification Site:	Thr446
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	420-470/551
Subcellular location:	Nucleus, Cytoplasm
Source:	KLH conjugated synthetic phosphopeptide derived from human PKR around the phosphorylation site of Thr446
Gene ID Number:	5610
Swiss Prot:	P19525
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs, Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6, Also phosphorylates other substrates including p53/TP53, Can act as both a positive and negative regulator of the insulin signaling pathway (ISP), DHX9, Either as an adapter protein and/or via its kinase activity, Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), ILF3, IRF1, IRS1 and the HHV-1 viral protein US11, In addition to serine/threonine-protein kinase activity, Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, PPP2R5A, STAT1, STAT3, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, apoptosis, can regulate various signaling pathways (p38 MAP kinase, cell proliferation and differentiation, facilitating its ubiquitination and proteosomal degradation, hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2), IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	553nm/568nm
Synonyms:	PKR EIF2AK1 PPP1R83
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	ALEXA FLUOR 555, Alexa Fluor
Gene target:	PKR (Thr446)
Short name:	PKR (Thr446) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 555
Alternative name:	ALEXA FLUOR 555, PKR (Thr446) (Antibody to)
Alternative technique:	antibodies
Identity:	9437
Gene:	EIF2AK2 | More about : EIF2AK2
Long gene name:	eukaryotic translation initiation factor 2 alpha kinase 2
Synonyms gene:	PRKR
Synonyms gene name:	interferon-inducible double stranded RNA dependent , protein kinase
Synonyms name:	protein phosphatase 1, regulatory subunit 83
Locus:	2p22, 2
Discovery year:	1992-12-04
GenBank acession:	BC057805
Entrez gene record:	5610
Pubmed identfication:	1351683
RefSeq identity:	NM_002759
Classification:	Protein phosphatase 1 regulatory subunits
Havana BLAST/BLAT:	OTTHUMG00000100962

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