| Long name: |
NMDAR2B (Tyr1070) Primary Polyclonal Antibody |
| Also known as: |
NMDAR2B (Tyr1070) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
NMDAR2B Tyr1070 |
| Specificity: |
This phosphorylated site is homologous to that of Tyr1070 in Mouse and Rat, This is a highly specific antibody against NMDAR2B Tyr1070 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Tyr1070 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1040-1090/1484 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human NMDAR2B around the phosphorylation site of Tyr1070 |
| Gene ID number: |
2904 |
| Swiss Prot: |
Q13224 |
| Tested Applications: |
FCM, IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
In concert with DAPK1 at extrasynaptic sites, Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, Mediated by glycine, acts as a central mediator for stroke damage, resulting in an irreversible neuronal death (By similarity), NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
GRIN2B, GluN2B, Glutamate [NMDA] receptor subunit epsilon-2, Glutamate receptor ionotropic, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NMDA 2B, NMDAR2B, NR2B, NR3, hNR3, MRD6 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NMDAR2B (Tyr1070) |
| Short name: |
NMDAR2B (Tyr1070) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NMDAR2B (Tyr1070) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4586 |
| Gene: |
GRIN2B |
More about : GRIN2B |
| Long gene name: |
glutamate ionotropic receptor NMDA type subunit 2B |
| Synonyms gene: |
NMDAR2B |
| Synonyms gene name: |
N-methyl D-aspartate 2B , glutamate receptor, ionotropic |
| Synonyms: |
GluN2B |
| Locus: |
12p13, 1 |
| Discovery year: |
1992-09-18 |
| Entrez gene record: |
2904 |
| Pubmed identfication: |
1350383 |
| Classification: |
Glutamate ionotropic receptor NMDA type subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000137373 |