| Long name: |
ALEXA FLUOR 350 Conjugated, MYPT1 (Ser507) Polyclonal Antibody |
| Also known as: |
Anti-MYPT1 Ser507 PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MYPT1 Ser507 |
| Specificity: |
This is a highly specific antibody against MYPT1 Ser507 |
| Modification: |
Phosphorylation |
| Modification Site: |
Ser507 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human MYPT1 around the phosphorylation site of Ser507 |
| Gene ID Number: |
4659 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho, Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase, Rho-associated kinase (Rho-kinase), RhoA, Several transcript variants encoding different isoforms have been found for this gene, The guanosine triphosphate(GTP)-bound, The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, Thus, [provided by RefSeq], active form of RhoA (GTP, is one of the subunits of myosin phosphatase, phosphorylated MBS and consequently inactivated myosin phosphatase, which is activated by GTP, which is also called the myosin-binding subunit of myosin phosphatase, which regulates the extent of phosphorylation of MLC, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells, Myosin phosphatase target subunit 1, RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
MBS M130 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
MYPT1 (Ser507) |
| Short name: |
MYPT1 (Ser507) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, MYPT1 (Ser507) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7618 |
| Gene: |
PPP1R12A |
More about : PPP1R12A |
| Long gene name: |
protein phosphatase 1 regulatory subunit 12A |
| Synonyms gene: |
MYPT1 |
| Synonyms gene name: |
protein phosphatase 1, regulatory (inhibitor) subunit 12A protein phosphatase 1, regulatory subunit 12A |
| Synonyms name: |
myosin phosphatase-targeting subunit 1 myosin binding subunit |
| Locus: |
12q21, 2-q21, 31 |
| Discovery year: |
1997-12-23 |
| GenBank acession: |
D87930 |
| Entrez gene record: |
4659 |
| Pubmed identfication: |
9286714 |
| RefSeq identity: |
NM_002480 |
| Classification: |
Ankyrin repeat domain containing Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000170100 |