| Long name: |
GAB2 (Tyr643) Primary Polyclonal Antibody |
| Also known as: |
GAB2 (Tyr643) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
GAB2 Tyr643 |
| Specificity: |
This is a highly specific antibody against GAB2 Tyr643 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Tyr643 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human GAB2 around the phosphorylation site of Thr643 |
| Gene ID number: |
9846 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
CrkL and SHC, Gab2 acts as a docking protein for several SH2-containing proteins, Gab2 interacts with SHP2 tyrosine phosphatase and GRB2 adaptor protein PI3-kinase, Gab2 is a substrate of various RTKs, Upon tyrosine phosphorylation, cytokine receptors as well as B and T cell antigen receptors, growth factors and cytokines, including EGFR, insulin receptor, Gab2 (Grb2-associated binder-2) is an adaptor protein involved in numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
GAB 2, GAB2_HUMAN, GRB 2 associated binding protein 2, GRB2 associated binder 2 pp100, GRB2 associated binder 2 pp100, GRB2 associated binding protein 2, GRB2-associated binder 2, GRB2-associated-binding protein 2, Gab2, Grb 2 associated binder 2, Grb2 associated binder 2, Growth factor receptor bound protein 2 associated protein 2, Growth factor receptor bound protein 2-associated protein 2, KIAA0571, PH domain containing adaptor molecule p97, p-GAB2 phospho Y643, p97, pp100, GAB2 phospho Y643 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
GAB2 (Tyr643) |
| Short name: |
GAB2 (Tyr643) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
GRB2-associated binding protein 2 (Tyr643) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
GAB2 and IDBG-65975 and ENSG00000033327 and 9846, Plasma membranes, phosphatidylinositol-3, this GO :0005068 and transmembrane receptor protein tyrosine kinase adaptor activity and molecular function this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005547 and phosphatidylinositol-3, this GO :0005068 : transmembrane receptor protein tyrosine kinase adaptor activity, this GO :0005068 : transmembrane receptor protein tyrosine kinase adaptor activity and also this GO :0005070 : SH3/SH2 adaptor activity and also this GO :0005515 : protein binding and also this GO :0005547 : phosphatidylinositol-3, this GO :0005070 : SH3/SH2 adaptor activity, this GO :0005515 : protein binding, this GO :0005547 : phosphatidylinositol-3, this GO :0043325 : phosphatidylinositol-3, 4, 4, 4, 4-bisphosphate binding, 4-bisphosphate binding, 4-bisphosphate binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process, 5-trisphosphate binding, 5-trisphosphate binding and also this GO :0043325 : phosphatidylinositol-3, 5-trisphosphate binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0030316 and osteoclast differentiation and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0043306 and positive regulation of mast cell degranulation and biological process this GO :0043325 and phosphatidylinositol-3, GRB2-associated binding protein 2 |
| Identity: |
14458 |
| Gene: |
GAB2 |
More about : GAB2 |
| Long gene name: |
GRB2 associated binding protein 2 |
| Synonyms: |
KIAA0571 |
| Synonyms name: |
Grb2-associated binder 2 |
| Locus: |
11q14, 1 |
| Discovery year: |
2001-01-24 |
| GenBank acession: |
AB011143 |
| Entrez gene record: |
9846 |
| Pubmed identfication: |
10391903 10068651 |
| RefSeq identity: |
NM_080491 |
| Classification: |
Pleckstrin homology domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000166673 |