| Long name: |
FITC Conjugated, RUNX1 (Ser266) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
RUNX1 Ser266 |
| Specificity: |
This is a highly specific antibody against RUNX1 Ser266 |
| Modification: |
Phosphorylation |
| Modification site: |
Ser266 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
240-280/453 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human RUNX1 around the phosphorylation site of Ser266 |
| Gene ID number: |
861 |
| Swiss Prot: |
Q01196 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
5'-PYGPYGGT-3', Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter, Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3, IL-3 and GM-CSF promoters, IL2RA and CTLA4, Inhibits KAT6B-dependent transcriptional activation, Isoform AML-1L interferes with the transactivation activity of RUNX1, LCK, T-cell receptor enhancers, The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis, in conventional T-cells (PubMed:17377532), including murine leukemia virus, of a number of enhancers and promoters, polyomavirus enhancer, CBF binds to the core site |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
PEBP2A2 AMLCR1 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
RUNX1 (Ser266) Conjugated |
| Short name: |
FITC Conjugated, RUNX1 (Ser266) Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, runt-related transcription factor 1 (Ser266) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AML1 and AML1-EVI-1 and AMLCR1 and CBFA2 and EVI-1 and PEBP2aB, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0007417 and central nervous system development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0009966 and regulation of signal transduction and biological process this GO :0030097 and hemopoiesis and biological process this GO :0030099 and myeloid cell differentiation and biological process this GO :0030182 and neuron differentiation and biological process this GO :0030853 and negative regulation of granulocyte differentiation and biological process this GO :0030854 and positive regulation of granulocyte differentiation and biological process this GO :0031069 and hair follicle morphogenesis and biological process this GO :0035162 and embryonic hemopoiesis and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048266 and behavioral response to pain and biological process this GO :0048666 and neuron development and biological process this GO :0048935 and peripheral nervous system neuron development and biological process this GO :0060216 and definitive hemopoiesis and biological process this GO :0070491 and repressing transcription factor binding and molecular function this GO :0071336 and regulation of hair follicle cell proliferation and biological process this GO :0071425 and hematopoietic stem cell proliferation and biological process this GO :0071560 and cellular response to transforming growth factor beta stimulus and biological process this GO :2000872 and positive regulation of progesterone secretion and biological process, RUNX1 and IDBG-2825 and ENSG00000159216 and 100506403, RUNX1 and IDBG-640443 and ENSBTAG00000004742 and 529631, Runx1 and IDBG-177713 and ENSMUSG00000022952 and 12394, nuclei, repressing transcription factor binding, this GO :0000975 and regulatory region DNA binding and molecular function this GO :0001501 and skeletal system development and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001889 and liver development and biological process this GO :0002318 and myeloid progenitor cell differentiation and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005604 and basement membrane and cellular component this GO :0005634 and nucleus and cellular component this GO :0006351 and transcription, this GO :0000975 : regulatory region DNA binding, this GO :0000975 : regulatory region DNA binding and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008134 : transcription factor binding and also this GO :0042803 : protein homodimerization activity and also this GO :0046982 : protein heterodimerization activity and also this GO :0070491 : repressing transcription factor binding, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005509 : calcium ion binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008134 : transcription factor binding, this GO :0042803 : protein homodimerization activity, this GO :0046982 : protein heterodimerization activity, this GO :0070491 : repressing transcription factor binding, 861, 101928269, runt-related transcription factor 1 |
| Identity: |
10471 |
| Gene: |
RUNX1 |
More about : RUNX1 |
| Long gene name: |
runt related transcription factor 1 |
| Synonyms gene: |
AML1 CBFA2 |
| Synonyms gene name: |
acute myeloid leukemia 1 runt-related transcription factor 1 |
| Synonyms name: |
aml1 oncogene |
| Locus: |
21q22, 12 |
| Discovery year: |
1991-08-20 |
| GenBank acession: |
X79549 |
| Entrez gene record: |
861 |
| Pubmed identfication: |
1427868 7835892 |
| Havana BLAST/BLAT: |
OTTHUMG00000086299 |
| Locus Specific Databases: |
LRG_482 |