| Long name: |
RUNX1 (Ser266) Primary Polyclonal Antibody |
| Also known as: |
RUNX1 (Ser266) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
RUNX1 Ser266 |
| Specificity: |
This is a highly specific antibody against RUNX1 Ser266 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser266 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
240-280/453 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human RUNX1 around the phosphorylation site of Ser266 |
| Gene ID number: |
861 |
| Swiss Prot: |
Q01196 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
5'-PYGPYGGT-3', Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter, Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3, IL-3 and GM-CSF promoters, IL2RA and CTLA4, Inhibits KAT6B-dependent transcriptional activation, Isoform AML-1L interferes with the transactivation activity of RUNX1, LCK, T-cell receptor enhancers, The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis, in conventional T-cells (PubMed:17377532), including murine leukemia virus, of a number of enhancers and promoters, polyomavirus enhancer, CBF binds to the core site |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
AML1-EVI-1, AMLCR1, Acute myeloid leukemia 1 protein, CBF-alpha-2, CBF2alpha, CBFA2, Core-binding factor subunit alpha-2, EVI-1, Oncogene AML-1, PEA2-alpha B, PEBP2-alpha B, PEBP2aB, PEBP2alpha, Polyomavirus enhancer-binding protein 2 alpha B subunit, RUNX1, Runt-related transcription factor 1, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit, AML1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
RUNX1 (Ser266) |
| Short name: |
RUNX1 (Ser266) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
runt-related transcription factor 1 (Ser266) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AML1 and AML1-EVI-1 and AMLCR1 and CBFA2 and EVI-1 and PEBP2aB, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0007417 and central nervous system development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0009966 and regulation of signal transduction and biological process this GO :0030097 and hemopoiesis and biological process this GO :0030099 and myeloid cell differentiation and biological process this GO :0030182 and neuron differentiation and biological process this GO :0030853 and negative regulation of granulocyte differentiation and biological process this GO :0030854 and positive regulation of granulocyte differentiation and biological process this GO :0031069 and hair follicle morphogenesis and biological process this GO :0035162 and embryonic hemopoiesis and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048266 and behavioral response to pain and biological process this GO :0048666 and neuron development and biological process this GO :0048935 and peripheral nervous system neuron development and biological process this GO :0060216 and definitive hemopoiesis and biological process this GO :0070491 and repressing transcription factor binding and molecular function this GO :0071336 and regulation of hair follicle cell proliferation and biological process this GO :0071425 and hematopoietic stem cell proliferation and biological process this GO :0071560 and cellular response to transforming growth factor beta stimulus and biological process this GO :2000872 and positive regulation of progesterone secretion and biological process, RUNX1 and IDBG-2825 and ENSG00000159216 and 100506403, RUNX1 and IDBG-640443 and ENSBTAG00000004742 and 529631, Runx1 and IDBG-177713 and ENSMUSG00000022952 and 12394, nuclei, repressing transcription factor binding, this GO :0000975 and regulatory region DNA binding and molecular function this GO :0001501 and skeletal system development and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001889 and liver development and biological process this GO :0002318 and myeloid progenitor cell differentiation and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005604 and basement membrane and cellular component this GO :0005634 and nucleus and cellular component this GO :0006351 and transcription, this GO :0000975 : regulatory region DNA binding, this GO :0000975 : regulatory region DNA binding and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008134 : transcription factor binding and also this GO :0042803 : protein homodimerization activity and also this GO :0046982 : protein heterodimerization activity and also this GO :0070491 : repressing transcription factor binding, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005509 : calcium ion binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008134 : transcription factor binding, this GO :0042803 : protein homodimerization activity, this GO :0046982 : protein heterodimerization activity, this GO :0070491 : repressing transcription factor binding, 861, 101928269, runt-related transcription factor 1 |
| Identity: |
10471 |
| Gene: |
RUNX1 |
More about : RUNX1 |
| Long gene name: |
runt related transcription factor 1 |
| Synonyms gene: |
AML1 CBFA2 |
| Synonyms gene name: |
acute myeloid leukemia 1 runt-related transcription factor 1 |
| Synonyms: |
PEBP2A2 AMLCR1 |
| Synonyms name: |
aml1 oncogene |
| Locus: |
21q22, 12 |
| Discovery year: |
1991-08-20 |
| GenBank acession: |
X79549 |
| Entrez gene record: |
861 |
| Pubmed identfication: |
1427868 7835892 |
| Havana BLAST/BLAT: |
OTTHUMG00000086299 |
| Locus Specific Databases: |
LRG_482 |