| Long name: |
Acinus (Ser1180) Primary Polyclonal Antibody |
| Also known as: |
Acinus (Ser1180) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Acinus Ser1180 |
| Specificity: |
The phosphorylation on Ser1180 is homologous to the phosphorylation at Ser1179 in mouse, This is a highly specific antibody against Acinus Ser1180 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser1180 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1150-1200/1341 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human Acinus around the phosphorylation site of Ser1180 |
| Gene ID number: |
22985 |
| Swiss Prot: |
Q9UKV3 |
| Tested Applications: |
IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ACIN1 confers RNA-binding to the complex, Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets, Induces apoptotic chromatin condensation after activation by CASP3, Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), Regulates cyclin A1, The ASAP complex can inhibit RNA processing during in vitro splicing reactions, The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis, The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism, but not cyclin A2, expression in leukemia cells, specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the activity is different from the established EJC assembly and function, Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ACIN1, ACINUS, Apoptotic chromatin condensation inducer in the nucleus, KIAA0670, fSAP152, ACN |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Acinus (Ser1180) |
| Short name: |
Acinus (Ser1180) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Acinus (Ser1180) (Antibody to) |
| Alternative technique: |
antibodies |