| Long name: |
Mitofusin 2 Primary Polyclonal Antibody |
| Also known as: |
Mitofusin 2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Mitofusin 2 |
| Specificity: |
This is a highly specific antibody against Mitofusin 2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1-50/757 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Mitofusin 2 |
| Gene ID number: |
9927 |
| Swiss Prot: |
O95140 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions, Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy), Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress, Is required for PARK2 recruitment to dysfunctional mitochondria, It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes, MFN2 acts independently of the cytoskeleton, Overexpression induces the formation of mitochondrial networks, Plays an important role in the regulation of vascular smooth muscle cell proliferation, which is balanced between fusion and fission, which mediates mitochondrial fusion, Essential transmembrane GTPase |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CMT2A, CMT2A2, CPRP1, KIAA0214, MARF, MFN2, Mitofusin-2, Transmembrane GTPase MFN2, HSG |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Mitofusin 2 |
| Short name: |
Mitofusin 2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Mitofusin 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16877 |
| Gene: |
MFN2 |
More about : MFN2 |
| Long gene name: |
mitofusin 2 |
| Synonyms: |
CPRP1 KIAA0214 MARF CMT2A2 |
| Locus: |
1p36, 22 |
| Discovery year: |
2003-02-25 |
| GenBank acession: |
AF036536 |
| Entrez gene record: |
9927 |
| Pubmed identfication: |
12499352 11181170 |
| RefSeq identity: |
NM_014874 |
| Havana BLAST/BLAT: |
OTTHUMG00000002392 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_255 |