| Long name: |
LRP5/6 Primary Polyclonal Antibody |
| Also known as: |
LRP5/6 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
LRP5 + LRP6 |
| Specificity: |
This is a highly specific antibody against LRP5 + LRP6 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
480-530/1613 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human LRP6 |
| Gene ID number: |
4040, 4041 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Dec 2009], LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands, The protein encoded by this gene functions as a receptor or, This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined, Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade, and migration and the development of many cancer types, proliferation, with Frizzled, This gene encodes a member of the low density lipoprotein (LDL) receptor gene family, [provided by RefSeq |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
C030016K15Rik, Cd, FLJ90062, FLJ90421, LR3, LRP-5, LRP-6, LRP6_HUMAN, LRP7, Low density lipoprotein receptor related protein 6, Low-density lipoprotein receptor-related protein 5, Low-density lipoprotein receptor-related protein 6, low-density lipoprotein receptor-related protein 6 precursor, ADCAD2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
LRP5/6 |
| Short name: |
LRP5/6 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
low density lipoprotein receptor-related protein 5/6 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BMND1 and EVR1 and EVR4 and HBM and LR3 and LRP-5 and LRP7 and OPPG and OPS and OPTA1 and VBCH2, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046849 and bone remodeling and biological process this GO :0046850 and regulation of bone remodeling and biological process this GO :0048539 and bone marrow development and biological process this GO :0048596 and embryonic camera-type eye morphogenesis and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0060033 and anatomical structure regression and biological process this GO :0060042 and retina morphogenesis in camera-type eye and biological process this GO :0060059 and embryonic retina morphogenesis in camera-type eye and biological process this GO :0060070 and canonical Wnt signaling pathway and biological process this GO :0060348 and bone development and biological process this GO :0060349 and bone morphogenesis and biological process this GO :0060444 and branching involved in mammary gland duct morphogenesis and biological process this GO :0060603 and mammary gland duct morphogenesis and biological process this GO :0060612 and adipose tissue development and biological process this GO :0060764 and cell-cell signaling involved in mammary gland development and biological process this GO :0060828 and regulation of canonical Wnt signaling pathway and biological process this GO :0061178 and regulation of insulin secretion involved in cellular response to glucose stimulus and biological process this GO :0061299 and retina vasculature morphogenesis in camera-type eye and biological process this GO :0061304 and retinal blood vessel morphogenesis and biological process this GO :0071901 and negative regulation of protein serine/threonine kinase activity and biological process this GO :1902262 and apoptotic process involved in patterning of blood vessels and biological process, LRP5 and IDBG-61383 and ENSG00000162337 and 4041, LRP5 and IDBG-644859 and ENSBTAG00000005903 and 534450, Lrp5 and IDBG-128306 and ENSMUSG00000024913 and 16973, Plasma membranes, Wnt-activated receptor activity, this GO :0001702 and gastrulation with mouth forming second and biological process this GO :0001944 and vasculature development and biological process this GO :0002053 and positive regulation of mesenchymal cell proliferation and biological process this GO :0002076 and osteoblast development and biological process this GO :0005515 and protein binding and molecular function this GO :0005739 and mitochondrion and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006007 and glucose catabolic process and biological process this GO :0006897 and endocytosis and biological process this GO :0008203 and cholesterol metabolic process and biological process this GO :0008217 and regulation of blood pressure and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009952 and anterior/posterior pattern specification and biological process this GO :0015026 and coreceptor activity and molecular function this GO :0016021 and integral component of membrane and cellular component this GO :0016055 and Wnt signaling pathway and biological process this GO :0017147 and Wnt-protein binding and molecular function this GO :0030326 and embryonic limb morphogenesis and biological process this GO :0033690 and positive regulation of osteoblast proliferation and biological process this GO :0035019 and somatic stem cell maintenance and biological process this GO :0035108 and limb morphogenesis and biological process this GO :0035426 and extracellular matrix-cell signaling and biological process this GO :0042074 and cell migration involved in gastrulation and biological process this GO :0042632 and cholesterol homeostasis and biological process this GO :0042733 and embryonic digit morphogenesis and biological process this GO :0042813 and Wnt-activated receptor activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043235 and receptor complex and cellular component this GO :0043434 and response to peptide hormone and biological process this GO :0044332 and Wnt signaling pathway involved in dorsal/ventral axis specification and biological process this GO :0045600 and positive regulation of fat cell differentiation and biological process this GO :0045668 and negative regulation of osteoblast differentiation and biological process this GO :0045840 and positive regulation of mitosis and biological process this GO :0045893 and positive regulation of transcription, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0015026 : coreceptor activity and also this GO :0017147 : Wnt-protein binding and also this GO :0042813 : Wnt-activated receptor activity, this GO :0015026 : coreceptor activity, this GO :0017147 : Wnt-protein binding, this GO :0042813 : Wnt-activated receptor activity, low density lipoprotein receptor-related protein 5 |
| Identity: |
6697 |
| Gene: |
LRP5 |
More about : LRP5 |
| Long gene name: |
LDL receptor related protein 5 |
| Synonyms gene: |
LRP7 OPPG EVR1 |
| Synonyms gene name: |
osteoporosis pseudoglioma syndrome exudative vitreoretinopathy 1 low density lipoprotein receptor-related protein 5 |
| Synonyms: |
LR3 BMND1 HBM OPS OPTA1 VBCH2 EVR4 |
| Locus: |
11q13, 2 |
| Discovery year: |
1998-04-07 |
| GenBank acession: |
AF064548 |
| Entrez gene record: |
4041 |
| Pubmed identfication: |
9714764 10049586 |
| RefSeq identity: |
NM_002335 |
| Classification: |
Low density lipoprotein receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000167570 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database |