| Long name: |
Biotin Conjugated, NEMO Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
NEMO |
| Specificity: |
This is a highly specific antibody against NEMO |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
370-419/419 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human NEMO |
| Gene ID number: |
8517 |
| Swiss Prot: |
Q9Y6K9 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Also considered to be a mediator for TAX activation of NF-kappa-B, Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity, Essential for viral activation of IRF3, However, Involved in TLR3- and IFIH1-mediated antiviral innate response, Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly, this function requires 'Lys-27'-linked polyubiquitination, Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
IKK-gamma NEMO Fip3p FIP-3 FIP3 ZC2HC9 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NEMO Conjugated |
| Short name: |
Conjugated, NEMO Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, NEMO (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5961 |
| Gene: |
IKBKG |
More about : IKBKG |
| Long gene name: |
inhibitor of nuclear factor kappa B kinase subunit gamma |
| Synonyms gene: |
IP2 IP1 |
| Synonyms gene name: |
incontinentia pigmenti inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma |
| Locus: |
Xq28 |
| Discovery year: |
1998-09-30 |
| GenBank acession: |
AF074382 |
| Entrez gene record: |
8517 |
| Pubmed identfication: |
9751060 10087442 11590134 |
| RefSeq identity: |
NM_003639 |
| Classification: |
Zinc fingers C2HC-type |
| Havana BLAST/BLAT: |
OTTHUMG00000024234 |
| Locus Specific Databases: |
IKBKGbase: Mutation registry for Nemo deficiency Mental Retardation database LRG_70 |