| Long name: |
ALEXA FLUOR 488 Conjugated, NEMO Polyclonal Antibody |
| Also known as: |
Anti-NEMO PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
NEMO |
| Specificity: |
This is a highly specific antibody against NEMO |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
370-419/419 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NEMO |
| Gene ID Number: |
8517 |
| Swiss Prot: |
Q9Y6K9 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Also considered to be a mediator for TAX activation of NF-kappa-B, Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity, Essential for viral activation of IRF3, However, Involved in TLR3- and IFIH1-mediated antiviral innate response, Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly, this function requires 'Lys-27'-linked polyubiquitination, Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
IKK-gamma NEMO Fip3p FIP-3 FIP3 ZC2HC9 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the NEMO Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
NEMO |
| Short name: |
NEMO Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, NEMO (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5961 |
| Gene: |
IKBKG |
More about : IKBKG |
| Long gene name: |
inhibitor of nuclear factor kappa B kinase subunit gamma |
| Synonyms gene: |
IP2 IP1 |
| Synonyms gene name: |
incontinentia pigmenti inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma |
| Locus: |
Xq28 |
| Discovery year: |
1998-09-30 |
| GenBank acession: |
AF074382 |
| Entrez gene record: |
8517 |
| Pubmed identfication: |
9751060 10087442 11590134 |
| RefSeq identity: |
NM_003639 |
| Classification: |
Zinc fingers C2HC-type |
| Havana BLAST/BLAT: |
OTTHUMG00000024234 |
| Locus Specific Databases: |
IKBKGbase: Mutation registry for Nemo deficiency Mental Retardation database LRG_70 |