| Long name: |
ALEXA FLUOR 488 Conjugated, Jak3 Polyclonal Antibody |
| Also known as: |
Anti-Jak3 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Jak3 |
| Specificity: |
This is a highly specific antibody against Jak3 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
610-660/1124 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Jak3 |
| Gene ID Number: |
3718 |
| Swiss Prot: |
P52333 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Following ligand binding to cell surface receptors, For example, IL15R and IL21R, IL4R, IL7R, IL9R, In the cytoplasm, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain, Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development, Once activated, Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription, STAT5A AND STAT5B are recruited, Subsequently, Then, creating docking sites for STATs proteins, development, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion, or differentiation, phosphorylated and activated by JAK1 and JAK3, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, phosphorylates the STATs proteins once they are recruited to the receptor, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, upon IL2R activation by IL2, Non-receptor tyrosine kinase involved in various processes such as cell growth |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
L-JAK JAKL LJAK JAK3_HUMAN JAK-3 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Jak3 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Jak3 |
| Short name: |
Jak3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, Janus kinase 3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6193 |
| Gene: |
JAK3 |
More about : JAK3 |
| Long gene name: |
Janus kinase 3 |
| Synonyms name: |
tyrosine-protein kinase JAK3 leukocyte Janus kinase |
| Locus: |
19p13, 11 |
| Discovery year: |
1994-12-19 |
| GenBank acession: |
U31601 |
| Entrez gene record: |
3718 |
| Pubmed identfication: |
8921370 9226382 |
| RefSeq identity: |
NM_000215 |
| Havana BLAST/BLAT: |
OTTHUMG00000165648 |
| Locus Specific Databases: |
JAK3base: Mutation registry for autosomal recessive severe combined JAK3 deficiency LRG_77 |