| Long name: |
AVEN Primary Polyclonal Antibody |
| Also known as: |
AVEN PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
AVEN |
| Specificity: |
This is a highly specific antibody against AVEN |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human AVEN |
| Gene ID number: |
57099 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
AVEN is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9, Disruption of this process has been implicated in a variety of diseases such as cancer, Higher levels of AVEN mRNA are seen in patients with acute leukemia than in control patients, It is thought that AVEN functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and removal of damaged cells, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that AVEN impedes Apaf-1-mediated caspase activation, suggesting that AVEN may be useful as a prognostic indicator in leukemia patients, tissue homeostasis, Apoptosis plays a major role in normal organism development |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
1700056A21Rik, AVEN_HUMAN, Apoptosis caspase activation inhibitor, Cell death regulator Aven, MGC124011, OTTMUSP00000016129, PDCD12, Programmed cell death 12, RP23-52C15, mAven L, mAven S, 1700013A01Rik, 2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
AVEN |
| Short name: |
AVEN Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
caspase activation inhibitor (Antibody to), apoptosis |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AVEN and IDBG-5324 and ENSG00000169857 and 57099, AVEN and IDBG-646114 and ENSBTAG00000044029 and 512666, Aven and IDBG-196731 and ENSMUSG00000003604 and 74268, Plasma membranes, caspase activation inhibitor, protein binding, this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0006915 and apoptotic process and biological process this GO :0012505 and endomembrane system and cellular component this GO :0016020 and membrane and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, apoptosis |
| Identity: |
13509 |
| Gene: |
AVEN |
More about : AVEN |
| Long gene name: |
apoptosis and caspase activation inhibitor |
| Synonyms: |
PDCD12 |
| Synonyms name: |
cell death regulator aven programmed cell death 12 |
| Locus: |
15q14 |
| Discovery year: |
2002-09-17 |
| GenBank acession: |
AF283508 |
| Entrez gene record: |
57099 |
| Pubmed identfication: |
10949025 |
| RefSeq identity: |
NM_020371 |
| Havana BLAST/BLAT: |
OTTHUMG00000129371 |