| Long name: |
APG7 Primary Polyclonal Antibody |
| Also known as: |
APG7 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
APG7 |
| Specificity: |
This is a highly specific antibody against APG7 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1-50/70 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ATG7 |
| Gene ID number: |
10533 |
| Swiss Prot: |
O95352 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine, Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes, Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress, Plays also a key role in the maintenance of axonal homeostasis, Required for autophagic death induced by caspase-8 inhibition, Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production, as well as in adipose differentiation, the formation of Paneth cell granules, the maintenance of hematopoietic stem cells, the prevention of axonal degeneration, E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
APG7-LIKE, APG7L, ATG12-activating enzyme E1 ATG7, ATG7, Autophagy-related protein 7, Ubiquitin-activating enzyme E1-like protein, Ubiquitin-like modifier-activating enzyme ATG7, hAGP7, GSA7 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
APG7 |
| Short name: |
APG7 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
APG7 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16935 |
| Gene: |
ATG7 |
More about : ATG7 |
| Long gene name: |
autophagy related 7 |
| Synonyms gene: |
APG7L |
| Synonyms gene name: |
APG7 autophagy 7-like (S, cerevisiae) , cerevisiae) ATG7 autophagy related 7 homolog (S |
| Synonyms: |
GSA7 DKFZp434N0735 |
| Synonyms name: |
ubiquitin-activating enzyme E1-like protein |
| Locus: |
3p25, 3 |
| Discovery year: |
2003-11-20 |
| GenBank acession: |
AF094516 |
| Entrez gene record: |
10533 |
| Pubmed identfication: |
10233149 |
| RefSeq identity: |
NM_006395 |
| Classification: |
Ubiquitin like modifier activating enzymes Autophagy related |
| Havana BLAST/BLAT: |
OTTHUMG00000129740 |