| Long name: |
Biotin Conjugated, MDC1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MDC1 |
| Specificity: |
This is a highly specific antibody against MDC1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
45-90/2089 |
| Source: |
KLH conjugated synthetic peptide derived from human MDC1 |
| Gene ID number: |
9656 |
| Swiss Prot: |
Q14676 |
| Tested applications: |
IHC-P |
| Recommended dilutions: |
IHC-P(1:100-500) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1, Also required for downstream events subsequent to the recruitment of these proteins, CHEK1 and CHEK2 kinases, May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX, These include phosphorylation and activation of the ATM, and stabilization of TP53 and apoptosis, Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
NFBD1 KIAA0170 Em:AB023051, 5 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MDC1 Conjugated |
| Short name: |
Conjugated, MDC1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, mediator on Desoxyribonucleic acid-damage checkpoint 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
FHA domain binding, MDC1 and IDBG-634528 and ENSBTAG00000025526 and 511168, MDC1 and IDBG-76700 and ENSG00000137337 and 9656, Mdc1 and IDBG-179187 and ENSMUSG00000061607 and 240087, NFBD1, nuclei, this GO :0000724 and double-strand break repair via homolo this GO us recombination and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005694 and chromosome and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0006281 and DNA repair and biological process this GO :0006302 and double-strand break repair and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0031573 and intra-S DNA damage checkpoint and biological process this GO :0070975 and FHA domain binding and molecular function, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008022 : protein C-terminus binding and also this GO :0070975 : FHA domain binding, this GO :0008022 : protein C-terminus binding, this GO :0070975 : FHA domain binding, mediator of DNA-damage checkpoint 1 |
| Identity: |
21163 |
| Gene: |
MDC1 |
More about : MDC1 |
| Long gene name: |
mediator of DNA damage checkpoint 1 |
| Synonyms gene name: |
mediator of DNA-damage checkpoint 1 |
| Locus: |
6p21, 33 |
| Discovery year: |
2003-05-21 |
| GenBank acession: |
D79992 |
| Entrez gene record: |
9656 |
| Pubmed identfication: |
10975465 12607005 |
| RefSeq identity: |
NM_014641 |
| Havana BLAST/BLAT: |
OTTHUMG00000031075 |