| Long name: |
Cy5, 5 Conjugated, FOXA2/HNF 3beta Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
FOXA2/HNF 3beta |
| Specificity: |
This is a highly specific antibody against FOXA2/HNF 3beta |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
200-250/457 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human HNF 3 beta |
| Gene ID number: |
3170 |
| Swiss Prot: |
Q9Y261 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity), Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation, FOXA1 and FOXA2 seem to have at least in part redundant roles, In embryonic development is required for notochord formation, Interacts with the cis-acting regulatory regions of these genes, Involved in glucose homeostasis, Involved in regulation of fat metabolism, Involved in the development of multiple endoderm-derived organ systems such as the liver, Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites, Originally described as a transcription activator for a number of liver genes such as AFP, PEPCK, albumin, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues, etc, pancreas and lungs, regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis, tyrosine aminotransferase, Transcription factor that is involved in embryonic development |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
FOXA2/HNF 3beta Conjugated |
| Short name: |
Conjugated, FOXA2/HNF 3beta Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, 5 coupled, forkhead box A2/HNF 3beta (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0007389 and pattern specification process and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008344 and adult locomotory behavior and biological process this GO :0009653 and anatomical structure morphogenesis and biological process this GO :0009952 and anterior/posterior pattern specification and biological process this GO :0009953 and dorsal/ventral pattern formation and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010719 and negative regulation of epithelial to mesenchymal transition and biological process this GO :0016568 and chromatin modification and biological process this GO :0019216 and regulation of lipid metabolic process and biological process this GO :0019218 and regulation of steroid metabolic process and biological process this GO :0019904 and protein domain specific binding and molecular function this GO :0021533 and cell differentiation in hindbrain and biological process this GO :0021904 and dorsal/ventral neural tube patterning and biological process this GO :0023019 and signal transduction involved in regulation of gene expression and biological process this GO :0030193 and regulation of blood coagulation and biological process this GO :0030324 and lung development and biological process this GO :0031018 and endocrine pancreas development and biological process this GO :0032525 and somite rostral/caudal axis specification and biological process this GO :0033132 and negative regulation of glucokinase activity and biological process this GO :0040019 and positive regulation of embryonic development and biological process this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045665 and negative regulation of neuron differentiation and biological process this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0045880 and positive regulation of smoothened signaling pathway and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0045945 and positive regulation of transcription from RNA polymerase III promoter and biological process this GO :0048468 and cell development and biological process this GO :0048646 and anatomical structure formation involved in morphogenesis and biological process this GO :0048665 and neuron fate specification and biological process this GO :0060441 and epithelial tube branching involved in lung morphogenesis and biological process this GO :0060487 and lung epithelial cell differentiation and biological process this GO :0061178 and regulation of insulin secretion involved in cellular response to glucose stimulus and biological process this GO :0061448 and connective tissue development and biological process this GO :0070741 and response to interleukin-6 and biological process this GO :0071542 and dopaminergic neuron differentiation and biological process this GO :0090009 and primitive streak formation and biological process this GO :2000049 and positive regulation of cell-cell adhesion mediated by cadherin and biological process this GO :2000543 and positive regulation of gastrulation and biological process this GO :2000971 and negative regulation of detection of glucose and biological process this GO :2000976 and regulation of transcription from RNA polymerase II promoter involved in detection of glucose and biological process, FOXA2 and IDBG-59234 and ENSG00000125798 and 3170, FOXA2 and IDBG-648756 and ENSBTAG00000012407 and 503580, Foxa2 and IDBG-208945 and ENSMUSG00000037025 and 15376, HNF3B and TCF3B, nuclei, this GO :0000432 and positive regulation of transcription from RNA polymerase II promoter by glucose and biological process this GO :0000433 and negative regulation of transcription from RNA polymerase II promoter by glucose and biological process this GO :0000978 and RNA polymerase II core promoter proximal region sequence-specific DNA binding and molecular function this GO :0001205 and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0001701 and in utero embryonic development and biological process this GO :0001705 and ectoderm formation and biological process this GO :0001708 and cell fate specification and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003705 and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006355 and regulation of transcription, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding and also this GO :0001205 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0019904 : protein domain specific binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0044212 : transcription regulatory region DNA binding, this GO :0001205 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0019904 : protein domain specific binding, this GO :0043565 : sequence-specific DNA binding, this GO :0044212 : transcription regulatory region DNA binding, transcription regulatory region DNA binding, forkhead box A2 |
| Identity: |
5022 |
| Gene: |
FOXA2 |
More about : FOXA2 |
| Long gene name: |
forkhead box A2 |
| Synonyms gene: |
HNF3B |
| Synonyms gene name: |
beta , hepatocyte nuclear factor 3 |
| Locus: |
20p11, 21 |
| Discovery year: |
1998-02-11 |
| GenBank acession: |
AF147787 |
| Entrez gene record: |
3170 |
| Pubmed identfication: |
9119385 11875061 |
| Classification: |
Forkhead boxes |
| Havana BLAST/BLAT: |
OTTHUMG00000191876 |