| Long name: |
Cy3 Conjugated, GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
cy3 conjugation kit |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
GSK3 Alpha/Beta Tyr279+Tyr216 |
| Specificity: |
This is a highly specific antibody against GSK3 Alpha/Beta Tyr279+Tyr216 |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr279+Tyr216 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
250-300/483 |
| Subcellular location: |
Cell membrane, Nucleus |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human GSK3 Alpha/Beta around the phosphorylation site of Tyr279/Tyr216 |
| Gene ID number: |
29312932 |
| Swiss Prot: |
P49840 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
APC and AXIN1, CTNNB1/beta-catenin, Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis, Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease, In Wnt signaling, Is necessary for the establishment of neuronal polarity and axon outgrowth, May also mediate the development of insulin resistance by regulating activation of transcription factors, May be involved in the regulation of replication in pancreatic beta-cells, Regulates glycogen metabolism in liver, Requires primed phosphorylation of the majority of its substrates, Through phosphorylation of the anti-apoptotic protein MCL1, Wnt signaling and regulation of transcription factors and microtubules, but not in muscle, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), may control cell apoptosis in response to growth factors deprivation, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin, Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
512, 550nm/570, 615nm |
| Synonyms: |
GSK-3 alpha, GSK3A, Serine/threonine-protein kinase GSK3A, Glycogen synthase kinase-3 alpha |
| Description: |
Conjugated is a &alpha, - or alpha protein sometimes glycoprotein present in blood, The GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody |
| Properties: |
1 of the GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
GSK3 Alpha/Beta(Tyr279+Tyr216) Conjugated |
| Short name: |
Conjugated, GSK3 Alpha/Beta(Tyr279+Tyr216) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy3 |
| Alternative name: |
cyanine 3 coupled, GSK3 a/b(Tyr279+Tyr216) (Antibody to) |
| Alternative technique: |
antibodies |