| Long name: |
Cy5, 5 Conjugated, Dematin Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Dematin |
| Specificity: |
This is a highly specific antibody against Dematin |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
250-280/405 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human Dematin |
| Gene ID number: |
2039 |
| Swiss Prot: |
Q08495 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Acts as a tumor suppressor and inhibits malignant cell transformation, Also required for the formation of a diverse set of cell protrusions, Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, In platelets, Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA), Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties, Plays also a role as a modulator of actin dynamics in fibroblasts, acts as a negative regulator of the RhoA activation pathway, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation, motility and migration, necessary for platelet cell spreading, such as filopodia and lamellipodia, Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Synonyms: |
DMTN, Dematin, Dematin actin-binding protein, EPB49, Erythrocyte membrane protein band 4, 9, DMT |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
Dematin Conjugated |
| Short name: |
Conjugated, Dematin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, 5 coupled, Dematin (Antibody to) |
| Alternative technique: |
antibodies |