| Long name: |
Dematin Primary Polyclonal Antibody |
| Also known as: |
Dematin PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Dematin |
| Specificity: |
This is a highly specific antibody against Dematin |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
250-280/405 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Dematin |
| Gene ID number: |
2039 |
| Swiss Prot: |
Q08495 |
| Tested Applications: |
IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Mouse, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as a tumor suppressor and inhibits malignant cell transformation, Also required for the formation of a diverse set of cell protrusions, Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, In platelets, Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA), Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties, Plays also a role as a modulator of actin dynamics in fibroblasts, acts as a negative regulator of the RhoA activation pathway, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation, motility and migration, necessary for platelet cell spreading, such as filopodia and lamellipodia, Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
DMTN, Dematin, Dematin actin-binding protein, EPB49, Erythrocyte membrane protein band 4, 9, DMT |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Dematin |
| Short name: |
Dematin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Dematin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3382 |
| Gene: |
DMTN |
More about : DMTN |
| Long gene name: |
dematin actin binding protein |
| Synonyms gene: |
EPB49 |
| Synonyms gene name: |
erythrocyte membrane protein band 4, 9 (dematin) |
| Synonyms: |
DMT |
| Locus: |
8p21, 3 |
| Discovery year: |
1995-09-29 |
| GenBank acession: |
U28389 |
| Entrez gene record: |
2039 |
| Pubmed identfication: |
8341682 12011427 |
| RefSeq identity: |
NM_001978 |
| Havana BLAST/BLAT: |
OTTHUMG00000097087 |