| Long name: |
TRF2 Primary Polyclonal Antibody |
| Also known as: |
TRF2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TRF2 |
| Specificity: |
This is a highly specific antibody against TRF2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
350-400/542 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TRF2 |
| Gene ID number: |
7014 |
| Swiss Prot: |
Q15554 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection, In addition to its telomeric DNA-binding role, Preferentially binds to positive supercoiled DNA, Recruits TERF2IP/RAP1 to telomeres, Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo, Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends, TERF2IP/RAP1 and DCLRE1B/Apollo, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology, Together with DCLRE1B/Apollo, Together with DCLRE1B/Apollo, including the shelterin complex, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair, required to control the amount of DNA topoisomerase (TOP1, required to recruit a number of factors and enzymes required for telomere protection, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length, without its protective activity, Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
TERF2, TRBF2, TTAGGG repeat-binding factor 2, Telomeric DNA-binding protein, Telomeric repeat-binding factor 2, TRF2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TRF2 |
| Short name: |
TRF2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TRF2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11729 |
| Gene: |
TERF2 |
More about : TERF2 |
| Long gene name: |
telomeric repeat binding factor 2 |
| Synonyms gene: |
TRBF2 |
| Synonyms: |
TRF2 |
| Locus: |
16q22, 1 |
| Discovery year: |
1997-11-20 |
| Entrez gene record: |
7014 |
| Pubmed identfication: |
9326950 10226653 |
| Classification: |
Shelterin complex Myb/SANT domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000137566 |