| Long name: |
ALEXA FLUOR 350 Conjugated, Parkin/PARK2 Polyclonal Antibody |
| Also known as: |
Anti-PARK2 PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PARK2 |
| Specificity: |
This is a highly specific antibody against PARK2 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
390-440/465 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human E3 ubiquitin-protein ligase parkin |
| Gene ID Number: |
5071 |
| Swiss Prot: |
O60260 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
CCNE1, GPR37, GPR37 accumulation, In collaboration with CHPF isoform 2, Independently of its ubiquitin ligase activity, Limits the production of reactive oxygen species (ROS), MFN1, MFN2, May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis, May protect neurons against alpha synuclein toxicity, May represent a tumor suppressor gene, Mediates 'Lys-48'-linked polyubiquitination of ZNF746, Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context, Mediates monoubiquitination of BCL2, Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by the ubiquitination of mitochondrial proteins such as TOMM2, RHOT1/MIRO1, RHOT1/MIRO1 and USP3 (PubMed:24896179), Regulates cyclin-E during neuronal apoptosis, SEPT5, STUB1, SYT11, TOMM2, USP3, ZNF746 and AIMP2, a 22 kDa O-linked glycosylated isoform of SNCAIP, and kainate-induced excitotoxicity, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, followed by degradation, followed by degradation of ZNF746 by the proteasome, leading to their recruitment to aggresomes, may enhance cell viability and protect cells from oxidative stress, possibly playing a role in Lewy-body formation, possibly playing a role in the regulation of neuron death, proteasomal dysfunction, protects from apoptosis by the transcriptional repression of p53/TP53, such as BCL2, thereby acting as a positive regulator of autophagy, Functions within a multiprotein E3 ubiquitin ligase complex |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
PDJ AR-JP parkin PRKN |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
Parkin/PARK2 |
| Short name: |
Parkin/PARK2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, Parkin/PARK2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8607 |
| Gene: |
PARK2 |
More about : PARK2 |
| Long gene name: |
parkin RBR E3 ubiquitin protein ligase |
| Synonyms gene name: |
E3 ubiquitin protein ligase (parkin) , Parkinson disease (autosomal recessive, juvenile) 2, parkin parkinson protein 2 |
| Synonyms name: |
E3 ubiquitin ligase |
| Locus: |
6q26 |
| Discovery year: |
1997-08-18 |
| Entrez gene record: |
5071 |
| Pubmed identfication: |
9560156 9570960 |
| Classification: |
Parkinson disease associated genes RBR E3 ubiquitin ligases |
| Havana BLAST/BLAT: |
OTTHUMG00000015970 |
| Locus Specific Databases: |
Parkinson', s disease Mutation Database |