| Long name: |
Biotin Conjugated, IL1RAP Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
IL1RAP |
| Specificity: |
This is a highly specific antibody against IL1RAP |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
300-335/570 |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from human IL1RAP/IL1R3 |
| Gene ID number: |
3556 |
| Swiss Prot: |
Q9NPH3 |
| Tested applications: |
WB |
| Recommended dilutions: |
WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways, Coreceptor with IL1R1 in the IL-1 signaling system, Does not bind to interleukin-1 alone, MYD88, Recruits TOLLIP to the signaling complex, Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, Signaling involves the recruitment of adapter molecules such as TOLLIP, The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors, Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
IL-1RAcP IL1R3 C3orf13 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
IL1RAP Conjugated |
| Short name: |
Conjugated, IL1RAP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, interleukin 1 receptor accessory protein (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
C3orf13 and IL-1RAcP and IL1R3, Extracellular, IL1RAP and IDBG-634437 and ENSBTAG00000013205 and 539334, IL1RAP and IDBG-69682 and ENSG00000196083 and 3556, Il1rap and IDBG-150439 and ENSMUSG00000022514 and 16180, protein binding, this GO :0004871 and signal transducer activity and molecular function this GO :0004908 and interleukin-1 receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006461 and protein complex assembly and biological process this GO :0006954 and inflammatory response and biological process this GO :0006955 and immune response and biological process this GO :0007165 and signal transduction and biological process this GO :0016020 and membrane and cellular component this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0042094 and interleukin-2 biosynthetic process and biological process this GO :0045087 and innate immune response and biological process, this GO :0004871 : signal transducer activity, this GO :0004871 : signal transducer activity and also this GO :0004908 : interleukin-1 receptor activity and also this GO :0005515 : protein binding, this GO :0004908 : interleukin-1 receptor activity, this GO :0005515 : protein binding, interleukin 1 receptor accessory protein |
| Identity: |
5995 |
| Gene: |
IL1RAP |
More about : IL1RAP |
| Long gene name: |
interleukin 1 receptor accessory protein |
| Locus: |
3q28 |
| Discovery year: |
1997-10-09 |
| GenBank acession: |
AB006537 |
| Entrez gene record: |
3556 |
| Pubmed identfication: |
9479509 9065432 |
| RefSeq identity: |
NM_001167929 |
| Classification: |
Immunoglobulin like domain containing Interleukin receptors TIR domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000156211 |