| Long name: |
Biotin Conjugated, DTNBP1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
DTNBP1 |
| Specificity: |
This is a highly specific antibody against DTNBP1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
130-180/351 |
| Subcellular location: |
Cytoplasm, Nucleus, Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from human DTNBP1 |
| Gene ID number: |
84062 |
| Swiss Prot: |
Q96EV8 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function, In concert with the AP-3 complex, May modulate MAPK8 phosphorylation, May play a role in actin cytoskeleton reorganization and neurite outgrowth, Modulates prefrontal cortical activity via the dopamine/D2 pathway, Plays a role in synaptic vesicle trafficking and in neurotransmitter release, Plays a role in the regulation of cell surface exposure of DRD2, Regulates the expression of SYN1 through binding to its promoter, The BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), in association with SNARE proteins, is also proposed to be involved in neurite extension, modulating PI3-kinase-Akt signaling and influencing glutamatergic release, such as platelet dense granules and melanosomes, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals, Component of the BLOC-1 complex |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
Dysbindin My031 HPS7 DBND BLOC1S8 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
DTNBP1 Conjugated |
| Short name: |
Conjugated, DTNBP1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, DTNBP1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
17328 |
| Gene: |
DTNBP1 |
More about : DTNBP1 |
| Long gene name: |
dystrobrevin binding protein 1 |
| Synonyms name: |
dysbindin-1 biogenesis of lysosomal organelles complex-1, subunit 8 |
| Locus: |
6p22, 3 |
| Discovery year: |
2002-01-15 |
| GenBank acession: |
AF394226 |
| Entrez gene record: |
84062 |
| Pubmed identfication: |
11316798 |
| RefSeq identity: |
NM_032122 |
| Classification: |
Biogenesis of lysosomal organelles complex 1 |
| Havana BLAST/BLAT: |
OTTHUMG00000014295 |
| Locus Specific Databases: |
LRG_588 |