| Long name: |
ALEXA FLUOR 647 Conjugated, HIC1 Polyclonal Antibody |
| Also known as: |
Anti-HIC1 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
HIC1 |
| Specificity: |
This is a highly specific antibody against HIC1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HIC1 |
| Gene ID Number: |
3090 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Conversely, HIC-1 does not interact with components of the HDAC complex, HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), HIC-1 is ubiquitously expressed in adult tissues and its structure is defined by five zinc fingers and an N-terminal broad complex POZ (or BTB) domain, In several BTB/POZ containing proteins, These and other studies indicate that HIC-1 acts as a putative tumor suppressor protein that mediates transcriptional repression, When this domain is deleted, and the expression of HIC-1 is also frequently suppressed in leukemia and various cancers due to the hypermethylation of specific DNA regions and the resulting transcriptional silencing, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, suggesting that HIC-1-induced transcriptional repression is unassociated with the POZ/BTB domain, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription, this transcriptional repression is attenuated, Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
ZBTB29 ZNF901 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the HIC1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
HIC1 |
| Short name: |
HIC1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, HIC1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4909 |
| Gene: |
HIC1 |
More about : HIC1 |
| Long gene name: |
HIC ZBTB transcriptional repressor 1 |
| Synonyms gene name: |
hypermethylated in cancer 1 |
| Locus: |
17p13, 3 |
| Discovery year: |
1996-03-19 |
| Entrez gene record: |
3090 |
| RefSeq identity: |
NM_006497 |
| Classification: |
BTB domain containing Zinc fingers C2H2-type |
| Havana BLAST/BLAT: |
OTTHUMG00000177635 |