| Long name: |
hHR23b Primary Polyclonal Antibody |
| Also known as: |
hHR23b PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
hHR23b |
| Specificity: |
This is a highly specific antibody against hHR23b |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
10-60/409 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human hHR23b |
| Gene ID number: |
5887 |
| Swiss Prot: |
P54727 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Binds to polyubiquitin chains, Cooperatively with CETN2 appears to stabilize XPC, Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation, In vitro, Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair, Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex, May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome, May protect XPC from proteasomal degradation, Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome, RPA and the TFIIH complex, The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, The orientation of XPC complex binding appears to be crucial for inducing a productive NER, XPA, XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery, is part of the pre-incision (or initial recognition) complex, it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts, mismatched bubbles or single-stranded overhangs, the XPC:RAD23B dimer is sufficient to initiate NER, Multiubiquitin chain receptor involved in modulation of proteasomal degradation |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
HHR23B, HR23B, RAD23B, UV excision repair protein RAD23 homolog B, XP-C repair-complementing complex 58 kDa protein, P58 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
hHR23b |
| Short name: |
hHR23b Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
hHR23b (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9813 |
| Gene: |
RAD23B |
More about : RAD23B |
| Long gene name: |
RAD23 homolog B, nucleotide excision repair protein |
| Synonyms gene name: |
RAD23 (S, cerevisiae) , cerevisiae) homolog B RAD23 homolog B (S |
| Synonyms: |
HHR23B P58 HR23B |
| Synonyms name: |
XP-C repair complementing protein XP-C repair complementing complex 58 kDa |
| Locus: |
9q31, 2 |
| Discovery year: |
1994-07-20 |
| Entrez gene record: |
5887 |
| Pubmed identfication: |
7851894 8168482 |
| RefSeq identity: |
NM_002874 |
| Classification: |
Nucleotide excision repair |
| Havana BLAST/BLAT: |
OTTHUMG00000020446 |