| Long name: |
HCST Primary Polyclonal Antibody |
| Also known as: |
HCST PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HCST |
| Specificity: |
This is a highly specific antibody against HCST |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1-50/93 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HCST |
| Gene ID number: |
10870 |
| Swiss Prot: |
Q9UBK5 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells, Functions as docking site for PI3-kinase PIK3R1 and GRB2, In NK cells, In T-cells, Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors, MAP2K/ERK, and JAK2/STAT5 signaling pathways, and UL16-binding proteins (ULBPs), indeed, it provides primarily costimulation for TCR-induced signals, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells, these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation, this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
DNAX-activation protein 10, HCST, Hematopoietic cell signal transducer, KAP10, Membrane protein DAP10, PIK3AP, Transmembrane adapter protein KAP10, UNQ587/PRO1157, DAP10 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HCST |
| Short name: |
HCST Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HCST (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11021 |
| Gene: |
SLC35A1 |
More about : SLC35A1 |
| Long gene name: |
solute carrier family 35 member A1 |
| Synonyms gene name: |
member 1 solute carrier family 35 (CMP-sialic acid transporter), member A1 , solute carrier family 35 (UDP-galactose transporter) |
| Synonyms: |
CMPST hCST |
| Locus: |
6q15 |
| Discovery year: |
1999-10-05 |
| GenBank acession: |
D87969 |
| Entrez gene record: |
10559 |
| Pubmed identfication: |
9010752 9644260 |
| Classification: |
Solute carriers |
| Havana BLAST/BLAT: |
OTTHUMG00000015177 |