| Long name: |
Biotin Conjugated, DTX3L Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
DTX3L |
| Specificity: |
This is a highly specific antibody against DTX3L |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
720-738/740 |
| Source: |
KLH conjugated synthetic peptide derived from human DTX3L |
| Gene ID number: |
151636 |
| Swiss Prot: |
Q8TDB6 |
| Tested applications: |
WB |
| Recommended dilutions: |
WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
In concert with PARP9, Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation, PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, Protects cells exposed to DNA-damaging agents, The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me), UIMC1/RAP80, and BRCA1 to DNA damage sites, in response to DNA damage, plays a role in PARP1-dependent DNA damage repair, Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
BBAP |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
DTX3L Conjugated |
| Short name: |
DTX3L Antibody Conjugated |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, DTX3L (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
30323 |
| Gene: |
DTX3L |
More about : DTX3L |
| Long gene name: |
deltex E3 ubiquitin ligase 3L |
| Synonyms gene name: |
deltex 3-like (Drosophila) |
| Synonyms name: |
rhysin 2 |
| Locus: |
3q21, 1 |
| Discovery year: |
2004-12-03 |
| Entrez gene record: |
151636 |
| Pubmed identfication: |
12670957 22411408 |
| RefSeq identity: |
NM_138287 |
| Classification: |
Ring finger proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000159524 |