| Long name: |
NOSTRIN Primary Polyclonal Antibody |
| Also known as: |
NOSTRIN PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
NOSTRIN |
| Specificity: |
This is a highly specific antibody against NOSTRIN |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NOSTRIN |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
It consists of an N-terminal Cdc15 domain with an FCH (Fes/CIP homology) region, It functions as an adaptor protein binding to caveolin-1 via an internal domain and NOS3 via its SH3 domain, NOSTRIN also interacts with Dynamin and N-WASP via its SH3 domain, NOSTRIN is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, NOSTRIN typically exists as a trimer, The NOS3 protein is responsible for the production of nitric oxide (NO), The translocation of NOS3 from the plasma membrane to intracellular vesicle-like structures diminishes NO production, a potent mediator in various biological processes, also known as endothelial nitric oxide synthase traffic inducer, forming a ternary complex which facilitates caveolar transport of NOS3, is a member of the Pombe Cdc15 homology (PCH) family of proteins, kidney and heart, lung, two coiled coil domains and a C-terminal SH3 domain, NOSTRIN (nitric oxide synthase trafficker isoform 1) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BM247 homolog, DaIP2, MGC20702, NOSTN_HUMAN, Nitric oxide synthase traffic inducer, Nitric oxide synthase trafficker, Nostrin, RP23-431D4, eNOS-trafficking inducer, mDaIP2, 2, BM247 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NOSTRIN |
| Short name: |
NOSTRIN Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
nitric oxide synthase trafficker (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, DNA-templated and biological process this GO :0046209 and nitric oxide metabolic process and biological process this GO :0050999 and regulation of nitric-oxide synthase activity and biological process, NOSTRIN and IDBG-74325 and ENSG00000163072 and 115677, Nostrin and IDBG-175946 and ENSMUSG00000034738 and 329416, nuclei, protein binding, this GO :0003677 and DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006897 and endocytosis and biological process this GO :0007165 and signal transduction and biological process this GO :0030666 and endocytic vesicle membrane and cellular component this GO :0044281 and small molecule metabolic process and biological process this GO :0045892 and negative regulation of transcription, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, 17865 and IDBG-641032 and ENSBTAG00000010362 and 521834, nitric oxide synthase trafficker |
| Identity: |
20203 |
| Gene: |
NOSTRIN |
More about : NOSTRIN |
| Long gene name: |
nitric oxide synthase trafficking |
| Synonyms gene name: |
nitric oxide synthase trafficker |
| Synonyms: |
MGC20702 |
| Locus: |
2q24, 3 |
| Discovery year: |
2003-01-06 |
| GenBank acession: |
AJ532842 |
| Entrez gene record: |
115677 |
| Pubmed identfication: |
12446846 |
| RefSeq identity: |
NM_052946 |
| Classification: |
F-BAR domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000153990 |