| Long name: |
Biotin Conjugated, NF2/Neurofibromin 2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
NF2/Neurofibromin 2 |
| Specificity: |
This is a highly specific antibody against NF2/Neurofibromin 2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
430-480/590 |
| Subcellular location: |
Intracellular |
| Source: |
KLH conjugated synthetic peptide derived from human NF2 |
| Gene ID number: |
4771 |
| Swiss Prot: |
P35240 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, May act as a membrane stabilizing protein, May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity, Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis, Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
merlin ACN SCH BANF |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NF2/Neurofibromin 2 Conjugated |
| Short name: |
Conjugated, NF2/Neurofibromin 2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, neurofibromin 2 (merlin)/Neurofibromin 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ACN and BANF and SCH, NF2 and IDBG-3678 and ENSG00000186575 and 4771, NF2 and IDBG-636202 and ENSBTAG00000013153 and 540479, Nf2 and IDBG-142996 and ENSMUSG00000009073 and 18016, cytoskeletal protein binding, nuclei, this GO :0001707 and mesoderm formation and biological process this GO :0001726 and ruffle and cellular component this GO :0001953 and negative regulation of cell-matrix adhesion and biological process this GO :0003779 and actin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005769 and early endosome and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005912 and adherens junction and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0007398 and ectoderm development and biological process this GO :0007420 and brain development and biological process this GO :0008092 and cytoskeletal protein binding and molecular function this GO :0008156 and negative regulation of DNA replication and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0014010 and Schwann cell proliferation and biological process this GO :0016020 and membrane and cellular component this GO :0019898 and extrinsic component of membrane and cellular component this GO :0021766 and hippocampus development and biological process this GO :0022408 and negative regulation of cell-cell adhesion and biological process this GO :0030027 and lamellipodium and cellular component this GO :0030036 and actin cytoskeleton organization and biological process this GO :0030175 and filopodium and cellular component this GO :0030336 and negative regulation of cell migration and biological process this GO :0030864 and cortical actin cytoskeleton and cellular component this GO :0031527 and filopodium membrane and cellular component this GO :0031647 and regulation of protein stability and biological process this GO :0032154 and cleavage furrow and cellular component this GO :0032587 and ruffle membrane and cellular component this GO :0035330 and regulation of hippo signaling and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042475 and odontogenesis of dentin-containing tooth and biological process this GO :0042518 and negative regulation of tyrosine phosphorylation of Stat3 protein and biological process this GO :0042524 and negative regulation of tyrosine phosphorylation of Stat5 protein and biological process this GO :0043409 and negative regulation of MAPK cascade and biological process this GO :0045177 and apical part of cell and cellular component this GO :0045216 and cell-cell junction organization and biological process this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0046426 and negative regulation of JAK-STAT cascade and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0051496 and positive regulation of stress fiber assembly and biological process this GO :0070306 and lens fiber cell differentiation and biological process this GO :1900180 and regulation of protein localization to nucleus and biological process this GO :2000177 and regulation of neural precursor cell proliferation and biological process, this GO :0003779 : actin binding, this GO :0003779 : actin binding and also this GO :0005515 : protein binding and also this GO :0008092 : cytoskeletal protein binding, this GO :0005515 : protein binding, this GO :0008092 : cytoskeletal protein binding, neurofibromin 2 (merlin) |
| Identity: |
7773 |
| Gene: |
NF2 |
More about : NF2 |
| Long gene name: |
neurofibromin 2 |
| Synonyms gene name: |
neurofibromin 2 (bilateral acoustic neuroma) neurofibromin 2 (merlin) |
| Synonyms name: |
moesin-ezrin-radixin like schwannomin |
| Locus: |
22q12, 2 |
| Discovery year: |
1992-01-01 |
| GenBank acession: |
L11353 |
| Entrez gene record: |
4771 |
| Pubmed identfication: |
10591208 |
| RefSeq identity: |
NM_000268 |
| Classification: |
A-kinase anchoring proteins FERM domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000030727 |
| Locus Specific Databases: |
Neurofibromatosis 2 (NF2) mutation database LRG_511 |