| Also known as: |
MYC / c-Myc |
| Other names: |
Class E basic helix-loop-helix protein 39, Myc proto-oncogene protein, Proto-oncogene c-Myc, Transcription factor p64, avian myelocytomatosis viral oncogene homolog, bHLHe39, class E basic helix-loop-helix protein 39, myc proto-oncogene protein, myc-related translation/localization regulatory factor, proto-oncogene c-Myc, transcription factor p64, v-myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog, myc proto-oncogene protein |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
MYC |
| Gene name synonims: |
c-Myc |
| Other gene names: |
BHLHE39, MRTL, MYC, MYCC, bHLHe39, bHLHe39, c-Myc, MYC |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
90000000000 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, Gorilla, Human (Homo sapiens) <, Monkey (at least 90% immunogen sequence identity), the reactivity of the antibody may extend to other species which are not listed hereby, /b>, Chimpanzee, Orangutan, Predicted Reactivity: <, b> |
| Specificity and cross-reactivity: |
ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation, In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The c-Myc protein is a transcription factor (nuclear localization), The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus, The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, This particular antibody might cross react with speacies outside of the listed ones, apoptosis and cell cycle progression, c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, cyclin-dependent kinase, differentiation, The antibody 9E10 may be used to detect the c-Myc tag |
| Purification method: |
Protein G Purified |
| Form/Appearance: |
15 mM sodium azide, approx, pH 7, 4, PBS |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
Cycles of freezing and defrosting may denaturate the polypeptide chains of the antibodies and reduce their activity, For longer storage the antibody should be kept at -20 degrees Celsius, For short term storage keep the antibody at +4 degrees Celsius |
| Tested applications:: |
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ 9E10] (IgG1) MYC / c-Myc |
| Short name: |
Mouse Monoclonal [clone 9E10] (IgG1) MYC / c-Myc Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
sapiens v-myc myelocytomatosis viral oncogene homolog (avian) / c-v-myc myelocytomatosis viral oncogene homolog (avian) (Antibody to), Mouse monoclonal [clonality 9E10] (IgG1) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Bmyc and IDBG-147082 and ENSMUSG00000049086 and 107771, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0006879 and cellular iron ion homeostasis and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0010332 and response to gamma radiation and biological process this GO :0010467 and gene expression and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0015671 and oxygen transport and biological process this GO :0032204 and regulation of telomere maintenance and biological process this GO :0032403 and protein complex binding and molecular function this GO :0032873 and negative regulation of stress-activated MAPK cascade and biological process this GO :0034644 and cellular response to UV and biological process this GO :0035690 and cellular response to drug and biological process this GO :0042493 and response to drug and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043234 and protein complex and cellular component this GO :0043280 and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0044346 and fibroblast apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045656 and negative regulation of monocyte differentiation and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046983 and protein dimerization activity and molecular function this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0048147 and negative regulation of fibroblast proliferation and biological process this GO :0050679 and positive regulation of epithelial cell proliferation and biological process this GO :0051276 and chromosome organization and biological process this GO :0051782 and negative regulation of cell division and biological process this GO :0060070 and canonical Wnt signaling pathway and biological process this GO :0070491 and repressing transcription factor binding and molecular function this GO :0070848 and response to growth factor and biological process this GO :0070888 and E-box binding and molecular function this GO :0090096 and positive regulation of metanephric cap mesenchymal cell proliferation and biological process this GO :2000573 and positive regulation of DNA biosynthetic process and biological process this GO :2001022 and positive regulation of response to DNA damage stimulus and biological process, E-box binding, MYC and IDBG-35442 and ENSG00000136997 and 4609, MYC and IDBG-644147 and ENSBTAG00000008409 and 511077, bHLHe39 and c-Myc and MRTL and MYCC, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000165 and MAPK cascade and biological process this GO :0000978 and RNA polymerase II core promoter proximal region sequence-specific DNA binding and molecular function this GO :0001077 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0001658 and branching involved in ureteric bud morphogenesis and biological process this GO :0002053 and positive regulation of mesenchymal cell proliferation and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0006112 and energy reserve metabolic process and biological process this GO :0006338 and chromatin remodeling and biological process this GO :0006351 and transcription, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding and also this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0032403 : protein complex binding and also this GO :0046983 : protein dimerization activity and also this GO :0070491 : repressing transcription factor binding and also this GO :0070888 : E-box binding, this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0032403 : protein complex binding, this GO :0046983 : protein dimerization activity, this GO :0070491 : repressing transcription factor binding, this GO :0070888 : E-box binding, v-myc myelocytomatosis viral oncogene homolog (avian) |
| Identity: |
7553 |
| Gene: |
MYC |
More about : MYC |
| Long gene name: |
v-myc avian myelocytomatosis viral oncogene homolog |
| Synonyms: |
c-Myc bHLHe39 MYCC |
| Locus: |
8q24, 21 |
| Discovery year: |
2001-06-22 |
| Entrez gene record: |
4609 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000128475 |