| Long name: |
ALEXA FLUOR 647 Conjugated, HCN2 + HCN4 Polyclonal Antibody |
| Also known as: |
Anti-HCN2 + HCN4 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
HCN2 + HCN4 |
| Specificity: |
This is a highly specific antibody against HCN2 + HCN4 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HCN2 + HCN4 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
HCN currents have been linked to pacemaker activity in the heart and brain, HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells, HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides, HCN2 is highly abundant in mamillary bodies, HCN4 is another member of the family of hyperpolarization activated and cyclic nucleotide gated channels, It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node, and nucleus of the trapezoid body, as well as, as well as neuronal plasticity, contribute to spontaneous rhythmic activity in both heart and brain, pontine nucleus, resting potential control, shaping autonomous activity of single neurons and the periodicity of network oscillations, ventral cochlear nucleus, Hyperpolarization activated cation channels of the HCN gene family such as HCN2 |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the HCN2 + HCN4 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
HCN2 + HCN4 |
| Short name: |
HCN2 + HCN4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, HCN2 and HCN4 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16882 |
| Gene: |
HCN4 |
More about : HCN4 |
| Long gene name: |
hyperpolarization activated cyclic nucleotide gated potassium channel 4 |
| Synonyms gene name: |
hyperpolarization activated cyclic nucleotide-gated potassium channel 4 |
| Locus: |
15q24, 1 |
| Discovery year: |
2002-09-02 |
| GenBank acession: |
AJ132429 |
| Entrez gene record: |
10021 |
| Pubmed identfication: |
10228147 10430953 16382102 |
| RefSeq identity: |
NM_005477 |
| Classification: |
Cyclic nucleotide gated channels |
| Havana BLAST/BLAT: |
OTTHUMG00000137563 |