| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PAPP-A |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the PAPP-A antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This PAPP-A antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
5069 |
| Purity: |
Antigen affinity |
| Description: |
It has been found that circulating PAPP-A is a disulfide-bridged complex with proMBP in which the subunits of the constituents are present in a 1:1 molar ratio, It is thought to be involved in local proliferative processes such as wound healing and bone remodeling, Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses, PAPP-A is found in the ovarian follicles, This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs), also known as DIPLA1, and fallopian tubes of nonpregnant women and in the seminal vesicles and seminal fluid of males, follicular fluid, is a protein that in humans is encoded by the PAPPA gene, luteal cells, Pappalysin-1 |
| Immunogen: |
Human partial recombinant protein (AA 95-388) was used as the immunogen for this PAPP-A antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the PAPP-A antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PAPP-A |
| Short name: |
PAPP-A Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PAPP-A (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8602 |
| Gene: |
PAPPA |
More about : PAPPA |
| Long gene name: |
pappalysin 1 |
| Synonyms gene name: |
pappalysin 1 , pregnancy-associated plasma protein A |
| Synonyms: |
PAPP-A PAPPA1 IGFBP-4ase PAPA ASBABP2 DIPLA1 |
| Synonyms name: |
insulin-like growth factor-dependent IGF binding protein-4 protease aspecific BCL2 ARE-binding protein 2 differentially placenta 1 expressed protein |
| Locus: |
9q33, 1 |
| Discovery year: |
1992-09-25 |
| Entrez gene record: |
5069 |
| Pubmed identfication: |
7679961 |
| RefSeq identity: |
NM_002581 |
| Classification: |
Sushi domain containing Pappalysins |
| Havana BLAST/BLAT: |
OTTHUMG00000021045 |