| Also known as: |
PAPP-A |
| Other names: |
IGF-dependent IGFBP-4 protease, IGF-dependent IGFBP-4 protease, IGFBP-4ase, Insulin-like growth factor-dependent IGF-binding protein 4 protease, Pappalysin-1, Pregnancy-associated plasma protein A, aspecific BCL2 ARE-binding protein 2, differentially placenta 1 expressed protein, insulin-like growth factor-dependent IGF binding protein-4 protease, insulin-like growth factor-dependent IGF-binding protein 4 protease, pappalysin 1, pappalysin-1, pregnacy-associated plasma protein A, pregnancy-associated plasma protein A, pappalysin-1 preproprotein |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
PAPP-A |
| Other gene names: |
ASBABP2, DIPLA1, IGF-dependent IGFBP-4 protease, IGFBP-4ase, IGFBP-4ase, PAPA, PAPP-A, PAPP-A, PAPPA, PAPPA1, PAPPA |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2b |
| Clone: |
100 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
400kDa form in unstable atherosclerotic plaques, As such, For an antibody that recognises only homodimeric PAPP-A MBS219141 is recommended, In pregnancy serum PAPP-A exists in a disulfide bound heterotetrameric complex consisting of two 200kDa PAPP-A subunits and two 50-90kDa subunits of the proform of eosinophil major basic protein (proMBP), Increased circulating concentrations of this dimeric PAPP-A are associated with acute coronary syndromes, PAPP-A is widely used as an early marker for Down's syndrome, PAPP-A was initially identified as a high-molecular mass component in human pregnancy serum, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The concentration of PAPP-A in serum increases with gestational age, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_PAPP-A has also been shown to exist in a homodimeric, _x000D__x000D_This item recognises both the heterotetrameric complex (PAPP-A associated with proMBP) and the homodimeric complex of PAPP-A, a metalloprotease specific for insulin-like growth factor binding protein-4 and -5 (IGFBP4 and IGFBP5), however, in Down's syndrome pregnancies PAPP-A concentration is markedly reduced in the first trimester, or PAPP-A, PAPP-A This item recognises human pregnancy-associated plasma protein A, _x000D__x000D_ |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
IgG concentration 1 miligram per 1 mililiter |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost free freezers is not recommended, the antibody should be stored undiluted, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
PAPP-A |
| Short name: |
MOUSE Anti-HUMAN PAPP-A Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens PAPP-A (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
8602 |
| Gene: |
PAPPA |
More about : PAPPA |
| Long gene name: |
pappalysin 1 |
| Synonyms gene name: |
pappalysin 1 , pregnancy-associated plasma protein A |
| Synonyms: |
PAPP-A PAPPA1 IGFBP-4ase PAPA ASBABP2 DIPLA1 |
| Synonyms name: |
insulin-like growth factor-dependent IGF binding protein-4 protease aspecific BCL2 ARE-binding protein 2 differentially placenta 1 expressed protein |
| Locus: |
9q33, 1 |
| Discovery year: |
1992-09-25 |
| Entrez gene record: |
5069 |
| Pubmed identfication: |
7679961 |
| RefSeq identity: |
NM_002581 |
| Classification: |
Sushi domain containing Pappalysins |
| Havana BLAST/BLAT: |
OTTHUMG00000021045 |