| Also known as: |
Myeloperoxidase |
| Other names: |
Myeloperoxidase, N/A, myeloperoxidase, myeloperoxidase, Myeloperoxidase |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
MPO, MPO, N/A, MPO |
| Gene name synonims: |
MPO, MPO, N/A, MPO |
| Other gene names: |
MPO, MPO, N/A, MPO |
| Clonality: |
Monoclonal antibody |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
8000000 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
, 50 ul of leukocytes containing 10^7 cells/ml are stained with 20 ul mAb of various dilutions to obtain a titration curve and to identify the saturation point and detection threshold, For this purpose, In addition and to control lot-to-lot variation, In practice, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The final concentration of the product is then adjusted to be at least 3-fold above the detection threshold, The sensitivity of MPO-C2 mAb is determined by staining well-defined blood samples from representative donors with serial-fold mAb dilutions to obtain a titration curve that allows relating the mAb concentration to the percentage of stained cells and geometric MFI (mean fluorescence intensity), This particular antibody might cross react with speacies outside of the listed ones, a mAb-concentration range is selected to include both the saturation point (i, the given lot is compared and adjusted to fluorescence standards with defined intensity, the mAb dilution expected to bind all epitopes on the target cell) and the detection threshold (i, the mAb dilution expected to represent the least amount of mAb needed to detect an identical percentage of cells), The MPO-C2 mAb (clone 8E2) reacts with human myeloperoxidase (MPO) expressed by normal and malignant myelomonocytic cells, e, e |
| Form/Appearance: |
0, 1% BSA, Storage buffer: PBS pH 7, 05% NaN3, 2, Purified by Chromatography |
| Storage and shipping: |
Keep the antibody at +4 degrees Celsius and do NOT freeze it, Please refer to the expiry date printed on the vial, The use of the reagent after the expiration date is not recommended, To enchance the antibody's stability sodium azide has been added, the antibody may be photosensitive, therefore avoid exposing the vial to direct bright light, the antibody contains monoclonal antibody specific reagents in optimal concentrations of affinity-purified antibody |
| Tested applications:: |
Flow Cytometry (FC/FACS) |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Myeloperoxidase (MPO) |
| Short name: |
Mouse Anti-Myeloperoxidase (MPO) |
| Technique: |
mouses, Mouse |
| Species: |
Mouses, Mouse |
| Alternative name: |
Mouse antibody to-Myeloperoxidase (myeloperoxidase) |
| Alternative technique: |
murine |
| Alternative to gene target: |
MPO and IDBG-60932 and ENSG00000005381 and 4353, MPO and IDBG-629390 and ENSBTAG00000011616 and 511206, Mpo and IDBG-207719 and ENSMUSG00000009350 and 17523, metal ion binding, nuclei, this GO :0001878 and response to yeast and biological process this GO :0002149 and hypochlorous acid biosynthetic process and biological process this GO :0002679 and respiratory burst involved in defense response and biological process this GO :0003682 and chromatin binding and molecular function this GO :0004601 and peroxidase activity and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005764 and lysosome and cellular component this GO :0006952 and defense response and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0007568 and aging and biological process this GO :0008201 and heparin binding and molecular function this GO :0009612 and response to mechanical stimulus and biological process this GO :0019430 and removal of superoxide radicals and biological process this GO :0020037 and heme binding and molecular function this GO :0030141 and secretory granule and cellular component this GO :0032094 and response to food and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0034374 and low-density lipoprotein particle remodeling and biological process this GO :0042582 and azurophil granule and cellular component this GO :0042744 and hydrogen peroxide catabolic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0044130 and negative regulation of growth of symbiont in host and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050832 and defense response to fungus and biological process this GO :0055114 and oxidation-reduction process and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :1990268 and response to this GO ld nanoparticle and biological process, this GO :0003682 : chromatin binding, this GO :0003682 : chromatin binding and also this GO :0004601 : peroxidase activity and also this GO :0008201 : heparin binding and also this GO :0020037 : heme binding and also this GO :0046872 : metal ion binding, this GO :0004601 : peroxidase activity, this GO :0008201 : heparin binding, this GO :0020037 : heme binding, this GO :0046872 : metal ion binding, myeloperoxidase |
| Identity: |
7218 |
| Gene: |
MPO |
More about : MPO |
| Long gene name: |
myeloperoxidase |
| Locus: |
17q22 |
| Discovery year: |
2001-06-22 |
| Entrez gene record: |
4353 |
| Havana BLAST/BLAT: |
OTTHUMG00000178922 |
| Locus Specific Databases: |
MPObase: Mutation registry for Myeloperoxidase deficiency LRG_84 |