| Also known as: |
C5AR1 / CD88 / C5a Receptor |
| Other names: |
C5a anaphylatoxin chemotactic receptor, C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin receptor, C5a ligand, C5a-R, C5a-R, C5aR, CD_antigen: CD88, complement component 5 receptor 1, complement component 5a receptor 1, C5a anaphylatoxin chemotactic receptor 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
C5AR1 |
| Other gene names: |
C5A, C5AR, C5AR, C5AR1, C5R1, C5R1, C5a-R, C5aR, CD88, C5AR1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
CD88 is expressed on granulocytes, Clone 10/92 does not block the binding of the C5a to murine CD88, In mouse, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The CD88 molecule functions as a receptor for the complement component C5a, This particular antibody might cross react with speacies outside of the listed ones, a 45kD G-protein coupled cell surface receptor, monocytes and macrophages but not on resting or stimulated lymphocytes, which is a potent proinflammatory molecule and a chemoattractant for neutrophils to sites of infection, which is otherwise known as C5aR, Recognizes murine CD88 |
| Purification method: |
Protein G Purified |
| Form/Appearance: |
0, pH 7, 09% sodium azide, 4, PBS |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
Cycles of freezing and defrosting may denaturate the polypeptide chains of the antibodies and reduce their activity, For longer storage the antibody should be kept at -20 degrees Celsius, For short term storage keep the antibody at +4 degrees Celsius |
| Tested applications:: |
Flow Cytometry (FC/FACS), IHC - Frozen), Immunohistochemistry (IHC - Paraffin |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Rats are used to make rat monoclonal anti mouse antibodies, Rats , There are less rat- than mouse clones however, Monoclonals of this antigen are available in different clones, Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats, genes from rodents , of the genus |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Rattus norvegicus, Mus musculus |
| Gene target: |
Monoclonal (IgG2a) C5AR1 / CD88 / C5a Receptor |
| Short name: |
Monoclonal (IgG2a) Mouse C5AR1 / CD88 / C5a Receptor Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Host: |
Rat |
| Isotype: |
IgG2a |
| Species: |
Mouses, Rats, Mouse |
| Alternative name: |
Rat monoclonal (IgG2a) to Mouse complement component 5a receptor 1 / CD88 / C5a Receptor (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, C5A and C5AR and C5R1 and CD88, C5AR1 and IDBG-59445 and ENSG00000197405 and 728, C5a anaphylatoxin receptor activity, C5ar1 and IDBG-146297 and ENSMUSG00000049130 and 12273, Cell surfaces, this GO :0000187 and activation of MAPK activity and biological process this GO :0001856 and complement component C5a binding and molecular function this GO :0002430 and complement receptor mediated signaling pathway and biological process this GO :0004878 and complement component C5a receptor activity and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004944 and C5a anaphylatoxin receptor activity and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006935 and chemotaxis and biological process this GO :0006954 and inflammatory response and biological process this GO :0006955 and immune response and biological process this GO :0006968 and cellular defense response and biological process this GO :0007165 and signal transduction and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007202 and activation of phospholipase C activity and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0007606 and sensory perception of chemical stimulus and biological process this GO :0009986 and cell surface and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016323 and basolateral plasma membrane and cellular component this GO :0021534 and cell proliferation in hindbrain and biological process this GO :0030593 and neutrophil chemotaxis and biological process this GO :0031100 and organ regeneration and biological process this GO :0032494 and response to peptidoglycan and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0038178 and complement component C5a signaling pathway and biological process this GO :0042789 and mRNA transcription from RNA polymerase II promoter and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045177 and apical part of cell and cellular component this GO :0050679 and positive regulation of epithelial cell proliferation and biological process this GO :0050830 and defense response to Gram-positive bacterium and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process, this GO :0001856 : complement component C5a binding, this GO :0001856 : complement component C5a binding and also this GO :0004878 : complement component C5a receptor activity and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0004944 : C5a anaphylatoxin receptor activity, this GO :0004878 : complement component C5a receptor activity, this GO :0004930 : G-protein coupled receptor activity, this GO :0004944 : C5a anaphylatoxin receptor activity, 34208 and IDBG-639986 and ENSBTAG00000020872 and 101908388, 493645, complement component 5a receptor 1 |
| Identity: |
1338 |
| Gene: |
C5AR1 |
More about : C5AR1 |
| Long gene name: |
complement C5a receptor 1 |
| Synonyms gene: |
C5R1 |
| Synonyms gene name: |
complement component 5 receptor 1 (C5a ligand) complement component 5a receptor 1 |
| Synonyms: |
C5A C5AR CD88 |
| Locus: |
19q13, 32 |
| Discovery year: |
1991-12-04 |
| Entrez gene record: |
728 |
| Pubmed identfication: |
1612600 |
| RefSeq identity: |
NM_001736 |
| Classification: |
Complement component GPCRs Complement system CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000183504 |