| Also known as: |
CA125 |
| Other names: |
CA-125, CA-125, CA125 ovarian cancer antigen, MUC-16, Mucin-16, Ovarian cancer-related tumor marker CA125, Ovarian carcinoma antigen CA125, cell surface associated, mucin 16, mucin-16, ovarian cancer-related tumor marker CA125, ovarian carcinoma antigen CA125, mucin-16 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CA125 |
| Other gene names: |
CA-125, CA125, CA125, MUC-16, MUC16, MUC16 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
X306 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CA125 consists of a short cytoplasmic tail, CA125 is present within normal ovarian, CA125 levels may also be elevated in other cancers and non-cancerous conditions such as peritonitis, Levels may also fluctuate during the menstrual cycle and occasionally increases in pregnancy, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The extracellular domain is dominated by a large number of 156-amino acid repeat units, The function of CA125 in healthy tissue is unknown but it is thought to provide a protective lubricating barrier against particles and infectious agents at mucosal surfaces, These repeats are known to bind the antibodies OC125 and M11, This item recognises the epitope specificity group A, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_CA125 was concluded by the International Society of Oncology and BioMarkers (ISOBM) to contain two major antigenic domains, a transmembrane domain and an exceptionally large glycosylated extracellular domain, but levels are elevated in over 90% of women with advanced ovarian cancer, endocervix and fallopian tissue, endometriosis and liver cirrhosis, endometrium, making CA125 an unreliable marker for ovarian cancer in premenopausal women, over 60 in all, similar to the OC125 antibody, CA125 This item recognises the ovarian cancer mucin CA125 (also known as MUCIN 16), _x000D__x000D_ |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Western Blot (WB), ELISA (EIA) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CA125 |
| Short name: |
MOUSE Anti-HUMAN CA125 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CA125 (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
15582 |
| Gene: |
MUC16 |
More about : MUC16 |
| Long gene name: |
cell surface associated , mucin 16 |
| Synonyms: |
CA125 FLJ14303 |
| Locus: |
19p13, 2 |
| Discovery year: |
2001-07-20 |
| GenBank acession: |
AF414442 |
| Entrez gene record: |
94025 |
| Pubmed identfication: |
11369781 |
| RefSeq identity: |
NM_024690 |
| Classification: |
Mucins |
| Havana BLAST/BLAT: |
OTTHUMG00000169191 |