| Long name: |
Recombinant Mouse CASP8 and FADD-like apoptosis regulator (Cflar) |
| Alternative names: |
CASH, CASP8 and FADD-like apoptosis regulator, CASP8 and FADD-like apoptosis regulator, CASP8 and FADD-like apoptosis regulator, CASP8 and FADD-like apoptosis regulator subunit p12, CLARP, Caspase homolog, Caspase-eight-related protein, Caspase-like apoptosis regulatory protein, Casper, Cellular FLICE-like inhibitory protein, FADD-like antiapoptotic molecule 1, FADD-like antiapoptotic molecule 1, FLAME-1, I-FLICE, Inhibitor of FLICE, MACH-related inducer of toxicity, MACH-related inducer of toxicity, MRIT, UsurpinCleaved into the following 2 chains:CASP8 and FADD-like apoptosis regulator subunit p43, c-FLIP, caspase homolog, caspase-eight-related protein, caspase-like apoptosis regulatory protein, cellular FLICE-like inhibitory protein, inhibitor of FLICE, usurpin, CASP8 and FADD-like apoptosis regulator isoform 1 |
| Gene name: |
Cflar |
| Other gene names: |
2310024N18Rik, A430105C05Rik, CASH, CLARP, CLARP, Cash, Cash, Casper, Casper, Cflar, ENSMUSG00000072980, FLAME, FLAME-1, FLAME-1, Flip, Gm9845, I-FLICE, I-FLICE, MRIT, MRIT, c-FLIP, c-Flip, Cflar |
| General description: |
All of our recombinant proteins are manufactured in strictly controlled facilities and by using a well established technology which guarantees full batch-to-bact consistency and experiment reproducibility, The protein can be with or without a His-Tag or other tag in accordance to customer's request, coli, CASP8 and FADD-like apoptosis regulator (Cflar) is a recombinant protein expressed in E |
| Product category: |
Recombinant Proteins |
| Expression system: |
coli, E |
| Available also expressed in:: |
Baculovirus , Mammalian Cell, Yeast , E Coli |
| Purity: |
Greater than 90% (determined by SDS-PAGE) |
| Form: |
Lyophilized protein |
| Storage: |
Avoid cycles of freezing and thawing as they might denaturate the polypeptide chains, For extended periods of time it is recommended to keep the protein frozen at -40 or -80 degrees Celsius, This protein can be stored at -20 degrees Celsius |
| Applications: |
IFA, RIA, Western Blot, etc, This protein can be used as a positive control for applications such as ELISA |
| Description: |
This 1 is suited for programmed cell-death studies |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
CASP8 FADD-like regulator (Cflar) |
| Short name: |
Mouse CASP8 FADD-like apoptosis regulator (Cflar) |
| Technique: |
apoptosis pathway, mouses, apoptosis |
| Species: |
Mouses, Mouse |
| Alternative name: |
apoptosis-related cysteine peptidase and Fas (TNF receptor superfamily, member 6) (TNFRSF6)-associated via death domain-like apoptosis regulator), member 6) (TNFRSF6)-associated via death domain-like programmed cellular destruction regulator (CASP8 and Fas (TNF receptor superfamily, Mouse caspase 8 |
| Alternative technique: |
celldeath |
| Alternative to gene target: |
ALPS2B and CAP4 and Casp-8 and FLICE and MACH and MCH5, CASP8 and IDBG-643207 and ENSBTAG00000015718 and 507481, CASP8 and IDBG-78534 and ENSG00000064012 and 841, Casp8 and IDBG-157464 and ENSMUSG00000026029 and 12370, FADD and IDBG-62144 and ENSG00000168040 and 8772, FADD and IDBG-645056 and ENSBTAG00000018274 and 493720, Fadd and IDBG-212910 and ENSMUSG00000031077 and 14082, MORT1, Plasma membranes, alpha-beta cytotoxic T cell extravasation and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process this GO :2001239 and regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, apoptosis-related cysteine peptidase, caspase 8, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, identical protein binding, leucine rich repeat containing receptor signaling pathway and biological process this GO :0035877 and death effector domain binding and molecular function this GO :0036462 and TRAIL-activated apoptotic signaling pathway and biological process this GO :0042110 and T cell activation and biological process this GO :0042113 and B cell activation and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043005 and neuron projection and cellular component this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043124 and negative regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043234 and protein complex and cellular component this GO :0044297 and cell body and cellular component this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045471 and response to ethanol and biological process this GO :0045651 and positive regulation of macrophage differentiation and biological process this GO :0045862 and positive regulation of proteolysis and biological process this GO :0046677 and response to antibiotic and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051603 and proteolysis involved in cellular protein catabolic process and biological process this GO :0060546 and negative regulation of necroptotic process and biological process this GO :0060715 and syncytiotrophoblast cell differentiation involved in labyrinthine layer development and biological process this GO :0070243 and regulation of thymocyte apoptotic process and biological process this GO :0070423 and nucleotide-binding oli this GO merization domain containing signaling pathway and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071407 and cellular response to organic cyclic compound and biological process this GO :0097110 and scaffold protein binding and molecular function this GO :0097153 and cysteine-type endopeptidase activity involved in apoptotic process and molecular function this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :0097194 and execution phase of apoptosis and biological process this GO :0097199 and cysteine-type endopeptidase activity involved in apoptotic signaling pathway and molecular function this GO :0097202 and activation of cysteine-type endopeptidase activity and biological process this GO :0097284 and hepatocyte apoptotic process and biological process this GO :0097342 and ripoptosome and cellular component this GO :1900740 and positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway and biological process this GO :2001233 and regulation of apoptotic signaling pathway and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process this GO :2001239 and regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, nuclei, this GO :0001525 and angiogenesis and biological process this GO :0001841 and neural tube formation and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004175 and endopeptidase activity and molecular function this GO :0004197 and cysteine-type endopeptidase activity and molecular function this GO :0005123 and death receptor binding and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005815 and microtubule organizing center and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0006508 and proteolysis and biological process this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0006921 and cellular component disassembly involved in execution phase of apoptosis and biological process this GO :0007507 and heart development and biological process this GO :0008233 and peptidase activity and molecular function this GO :0008234 and cysteine-type peptidase activity and molecular function this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0009409 and response to cold and biological process this GO :0016032 and viral process and biological process this GO :0030101 and natural killer cell activation and biological process this GO :0030225 and macrophage differentiation and biological process this GO :0030690 and Noc1p-Noc2p complex and cellular component this GO :0031264 and death-inducing signaling complex and cellular component this GO :0031265 and CD95 death-inducing signaling complex and cellular component this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032025 and response to cobalt ion and biological process this GO :0032355 and response to estradiol and biological process this GO :0032403 and protein complex binding and molecular function this GO :0032496 and response to lipopolysaccharide and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034612 and response to tumor necrosis factor and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035872 and nucleotide-binding domain, this GO :0001916 and positive regulation of T cell mediated cytotoxicity and biological process this GO :0002020 and protease binding and molecular function this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0002821 and positive regulation of adaptive immune response and biological process this GO :0005123 and death receptor binding and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0016032 and viral process and biological process this GO :0031264 and death-inducing signaling complex and cellular component this GO :0031265 and CD95 death-inducing signaling complex and cellular component this GO :0032403 and protein complex binding and molecular function this GO :0032729 and positive regulation of interferon-gamma production and biological process this GO :0032757 and positive regulation of interleukin-8 production and biological process this GO :0032760 and positive regulation of tumor necrosis factor production and biological process this GO :0032813 and tumor necrosis factor receptor superfamily binding and molecular function this GO :0033077 and T cell differentiation in thymus and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035877 and death effector domain binding and molecular function this GO :0036462 and TRAIL-activated apoptotic signaling pathway and biological process this GO :0042104 and positive regulation of activated T cell proliferation and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043005 and neuron projection and cellular component this GO :0043029 and T cell homeostasis and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043234 and protein complex and cellular component this GO :0044297 and cell body and cellular component this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045651 and positive regulation of macrophage differentiation and biological process this GO :0045862 and positive regulation of proteolysis and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048535 and lymph node development and biological process this GO :0048536 and spleen development and biological process this GO :0048538 and thymus development and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051607 and defense response to virus and biological process this GO :0060340 and positive regulation of type I interferon-mediated signaling pathway and biological process this GO :0060546 and negative regulation of necroptotic process and biological process this GO :0070236 and negative regulation of activation-induced cell death of T cells and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0097049 and motor neuron apoptotic process and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :0097202 and activation of cysteine-type endopeptidase activity and biological process this GO :0097342 and ripoptosome and cellular component this GO :0097527 and necroptotic signaling pathway and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :2000454 and positive regulation of CD8-positive, this GO :0002020 : protease binding, this GO :0002020 : protease binding and also this GO :0005123 : death receptor binding and also this GO :0005164 : tumor necrosis factor receptor binding and also this GO :0005515 : protein binding and also this GO :0032403 : protein complex binding and also this GO :0032813 : tumor necrosis factor receptor superfamily binding and also this GO :0035877 : death effector domain binding and also this GO :0042802 : identical protein binding, this GO :0004175 : endopeptidase activity, this GO :0004175 : endopeptidase activity and also this GO :0004197 : cysteine-type endopeptidase activity and also this GO :0005123 : death receptor binding and also this GO :0005164 : tumor necrosis factor receptor binding and also this GO :0005515 : protein binding and also this GO :0008233 : peptidase activity and also this GO :0008234 : cysteine-type peptidase activity and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0032403 : protein complex binding and also this GO :0035877 : death effector domain binding and also this GO :0046982 : protein heterodimerization activity and also this GO :0097110 : scaffold protein binding and also this GO :0097153 : cysteine-type endopeptidase activity involved in apoptotic process and also this GO :0097199 : cysteine-type endopeptidase activity involved in apoptotic signaling pathway, this GO :0004197 : cysteine-type endopeptidase activity, this GO :0005123 : death receptor binding, this GO :0005123 : death receptor binding, this GO :0005164 : tumor necrosis factor receptor binding, this GO :0005164 : tumor necrosis factor receptor binding, this GO :0005515 : protein binding, this GO :0005515 : protein binding, this GO :0008233 : peptidase activity, this GO :0008234 : cysteine-type peptidase activity, this GO :0031625 : ubiquitin protein ligase binding, this GO :0032403 : protein complex binding, this GO :0032403 : protein complex binding, this GO :0032813 : tumor necrosis factor receptor superfamily binding, this GO :0035877 : death effector domain binding, this GO :0035877 : death effector domain binding, this GO :0042802 : identical protein binding, this GO :0046982 : protein heterodimerization activity, this GO :0097110 : scaffold protein binding, this GO :0097153 : cysteine-type endopeptidase activity involved in apoptotic process, this GO :0097199 : cysteine-type endopeptidase activity involved in apoptotic signaling pathway, Fas (TNFRSF6)-associated via death domain |
| Identity: |
1509 |
| Gene: |
CASP8 |
More about : CASP8 |
| Long gene name: |
caspase 8 |
| Synonyms gene name: |
apoptosis-related cysteine peptidase , apoptosis-related cysteine protease caspase 8, caspase 8 |
| Synonyms: |
MCH5 MACH FLICE Casp-8 |
| Locus: |
2q33, 1 |
| Discovery year: |
1996-11-11 |
| GenBank acession: |
U60520 |
| Entrez gene record: |
841 |
| Pubmed identfication: |
8681376 8681377 |
| RefSeq identity: |
NM_001228 |
| Classification: |
Caspases Death effector domain containing Ripoptosome Death inducing signaling complex |
| Havana BLAST/BLAT: |
OTTHUMG00000132821 |
| Locus Specific Databases: |
CASP8base: Mutation registry for Caspase 8 deficiency LRG_34 |