| Long name: |
FITC Conjugated, SOCS5 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SOCS5 |
| Specificity: |
This is a highly specific antibody against SOCS5 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human SOCS5 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5, SOCS2, SOCS3, SOCS4, SOCS5, SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation, SOCS6, SOCS7, Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development, The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction, Therefore, This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation, Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, a central SH2 domain, and CIS, and a C-terminal motif called the SOCS box, and once produced, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance, the various members of the SOCS family appear to inhibit signaling in different ways, The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
KIAA0671 SOCS-5 CIS6 CISH6 Cish5 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
SOCS5 Conjugated |
| Short name: |
FITC Conjugated, SOCS5 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, suppressor on cytokine signaling 5 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, CIS6 and Cish5 and CISH6 and SOCS-5, SOCS5 and IDBG-50628 and ENSG00000171150 and 9655, Socs5 and IDBG-201346 and ENSMUSG00000037104 and 56468, multiple, receptor tyrosine kinase binding, this GO :0005154 and epidermal growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007175 and negative regulation of epidermal growth factor-activated receptor activity and biological process this GO :0007259 and JAK-STAT cascade and biological process this GO :0009968 and negative regulation of signal transduction and biological process this GO :0016049 and cell growth and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0030971 and receptor tyrosine kinase binding and molecular function this GO :0032436 and positive regulation of proteasomal ubiquitin-dependent protein catabolic process and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0040008 and regulation of growth and biological process this GO :0045087 and innate immune response and biological process this GO :0045627 and positive regulation of T-helper 1 cell differentiation and biological process this GO :0045629 and negative regulation of T-helper 2 cell differentiation and biological process, this GO :0005154 : epidermal growth factor receptor binding, this GO :0005154 : epidermal growth factor receptor binding and also this GO :0005515 : protein binding and also this GO :0030971 : receptor tyrosine kinase binding, this GO :0005515 : protein binding, this GO :0030971 : receptor tyrosine kinase binding, 58314 and IDBG-633338 and ENSBTAG00000008987 and 514773, suppressor of cytokine signaling 5 |
| Identity: |
16852 |
| Gene: |
SOCS5 |
More about : SOCS5 |
| Long gene name: |
suppressor of cytokine signaling 5 |
| Locus: |
2p21 |
| Discovery year: |
2002-11-13 |
| GenBank acession: |
AB014571 |
| Pubmed identfication: |
9734811 11230166 |
| Classification: |
Suppressors of cytokine signaling SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000128852 |