| Long name: |
FITC Conjugated, MCL1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MCL1 |
| Specificity: |
This is a highly specific antibody against MCL1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
210-248/350 |
| Subcellular location: |
Helical |
| Source: |
KLH conjugated synthetic peptide derived from human MCL1 |
| Gene ID number: |
4170 |
| Swiss Prot: |
Q07820 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Isoform 1 inhibits apoptosis, Isoform 2 promotes apoptosis, Mediates its effects by interactions with a number of other regulators of apoptosis, and in the maintenance of viability but not of proliferation, Involved in the regulation of apoptosis versus cell survival |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
BCL2L3 Mcl-1 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MCL1 Conjugated |
| Short name: |
FITC Conjugated, MCL1 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, myeloid cell leukemia sequence 1 (BCL2-related) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BH3 domain binding, MCL1 and IDBG-102145 and ENSG00000143384 and 4170, Mcl1 and IDBG-173221 and ENSMUSG00000038612 and 17210, bcl2-L-3 and BCL2L3 and EAT and Mcl-1 and MCL1-ES and mcl1/EAT and MCL1L and MCL1S and TM, nuclei, this GO :0001709 and cell fate determination and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005759 and mitochondrial matrix and cellular component this GO :0005829 and cytosol and cellular component this GO :0007275 and multicellular organismal development and biological process this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0008637 and apoptotic mitochondrial changes and biological process this GO :0015266 and protein channel activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019725 and cellular homeostasis and biological process this GO :0034097 and response to cytokine and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0051434 and BH3 domain binding and molecular function this GO :0071806 and protein transmembrane transport and biological process this GO :0097136 and Bcl-2 family protein complex and cellular component this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :0097194 and execution phase of apoptosis and biological process this GO :1900118 and negative regulation of execution phase of apoptosis and biological process this GO :2000811 and negative regulation of anoikis and biological process this GO :2001020 and regulation of response to DNA damage stimulus and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :2001243 and negative regulation of intrinsic apoptotic signaling pathway and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0015266 : protein channel activity and also this GO :0042803 : protein homodimerization activity and also this GO :0046982 : protein heterodimerization activity and also this GO :0051434 : BH3 domain binding, this GO :0015266 : protein channel activity, this GO :0042803 : protein homodimerization activity, this GO :0046982 : protein heterodimerization activity, this GO :0051434 : BH3 domain binding, myeloid cell leukemia sequence 1 (BCL2-related) |
| Identity: |
6943 |
| Gene: |
MCL1 |
More about : MCL1 |
| Long gene name: |
BCL2 family apoptosis regulator |
| Synonyms gene name: |
myeloid cell leukemia sequence 1 (BCL2-related) myeloid cell leukemia 1 |
| Locus: |
1q21, 2 |
| Discovery year: |
1993-11-09 |
| GenBank acession: |
BC017197 |
| Entrez gene record: |
4170 |
| Pubmed identfication: |
7682708 7835896 |
| RefSeq identity: |
NM_021960 |
| Classification: |
BCL2 family |
| Havana BLAST/BLAT: |
OTTHUMG00000034867 |