| Long name: |
Cy5 Conjugated, FADD (Ser194) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
FADD Ser194 |
| Specificity: |
This is a highly specific antibody against FADD Ser194 |
| Modification: |
Phosphorylation |
| Modification site: |
Ser194 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from rat protein FADD around the phosphorylation site of Ser194 |
| Gene ID number: |
266610 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Rat |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Activated Caspase 8 then activates other downstream caspases including Caspase 9, FADD also interacts with the hepatitis C virus core protein in the HEK 293 cell line, FADD is implicated in non-apoptotic cellular pathways such as the regulation of cell cycle machinery in T lymphocytes, Recruitment of Caspase 8 to the Fas receptor results in oligomerization of the Caspase 8 protein, The N terminus contains a death effectors domain (DED) which recruits caspase to the death inducing signaling complex (DISC) and initiates the apoptotic caspase cascade, The protein contains a C terminal death domain that interacts with the Fas receptor death domain, This is connected to the phosphorylation state of FADD and to the FasL/TRAIL induced transcriptional activation of cfos protooncogene, thereby commiting the cell to undergo apoptosis, which in turn drives its autoactivation through self-cleavage, FADD (Fas Associated Death Domain) is an apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via the FasL/Fas receptor interaction |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
625, 650nm/670nm |
| Synonyms: |
MORT1 GIG3 |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
FADD (Ser194) Conjugated |
| Short name: |
Conjugated, FADD (Ser194) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy5 |
| Alternative name: |
cyanine 5 coupled, member 6) (TNFRSF6)-associated via death domain (Ser194) (Antibody to), Fas (TNF receptor superfamily |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
FADD and IDBG-62144 and ENSG00000168040 and 8772, FADD and IDBG-645056 and ENSBTAG00000018274 and 493720, Fadd and IDBG-212910 and ENSMUSG00000031077 and 14082, MORT1, Plasma membranes, alpha-beta cytotoxic T cell extravasation and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process this GO :2001239 and regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, identical protein binding, this GO :0001916 and positive regulation of T cell mediated cytotoxicity and biological process this GO :0002020 and protease binding and molecular function this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0002821 and positive regulation of adaptive immune response and biological process this GO :0005123 and death receptor binding and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0016032 and viral process and biological process this GO :0031264 and death-inducing signaling complex and cellular component this GO :0031265 and CD95 death-inducing signaling complex and cellular component this GO :0032403 and protein complex binding and molecular function this GO :0032729 and positive regulation of interferon-gamma production and biological process this GO :0032757 and positive regulation of interleukin-8 production and biological process this GO :0032760 and positive regulation of tumor necrosis factor production and biological process this GO :0032813 and tumor necrosis factor receptor superfamily binding and molecular function this GO :0033077 and T cell differentiation in thymus and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0035877 and death effector domain binding and molecular function this GO :0036462 and TRAIL-activated apoptotic signaling pathway and biological process this GO :0042104 and positive regulation of activated T cell proliferation and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043005 and neuron projection and cellular component this GO :0043029 and T cell homeostasis and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043234 and protein complex and cellular component this GO :0044297 and cell body and cellular component this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045651 and positive regulation of macrophage differentiation and biological process this GO :0045862 and positive regulation of proteolysis and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048535 and lymph node development and biological process this GO :0048536 and spleen development and biological process this GO :0048538 and thymus development and biological process this GO :0051291 and protein heterooli this GO merization and biological process this GO :0051607 and defense response to virus and biological process this GO :0060340 and positive regulation of type I interferon-mediated signaling pathway and biological process this GO :0060546 and negative regulation of necroptotic process and biological process this GO :0070236 and negative regulation of activation-induced cell death of T cells and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0097049 and motor neuron apoptotic process and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :0097202 and activation of cysteine-type endopeptidase activity and biological process this GO :0097342 and ripoptosome and cellular component this GO :0097527 and necroptotic signaling pathway and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :2000454 and positive regulation of CD8-positive, this GO :0002020 : protease binding, this GO :0002020 : protease binding and also this GO :0005123 : death receptor binding and also this GO :0005164 : tumor necrosis factor receptor binding and also this GO :0005515 : protein binding and also this GO :0032403 : protein complex binding and also this GO :0032813 : tumor necrosis factor receptor superfamily binding and also this GO :0035877 : death effector domain binding and also this GO :0042802 : identical protein binding, this GO :0005123 : death receptor binding, this GO :0005164 : tumor necrosis factor receptor binding, this GO :0005515 : protein binding, this GO :0032403 : protein complex binding, this GO :0032813 : tumor necrosis factor receptor superfamily binding, this GO :0035877 : death effector domain binding, this GO :0042802 : identical protein binding, Fas (TNFRSF6)-associated via death domain |
| Identity: |
3573 |
| Gene: |
FADD |
More about : FADD |
| Long gene name: |
Fas associated via death domain |
| Synonyms gene name: |
Fas (TNFRSF6)-associated via death domain |
| Synonyms name: |
Fas-associating protein with death domain Fas-associating death domain-containing protein mediator of receptor-induced toxicity growth-inhibiting gene 3 protein |
| Locus: |
11q13, 3 |
| Discovery year: |
1999-05-07 |
| GenBank acession: |
U24231 |
| Entrez gene record: |
8772 |
| Pubmed identfication: |
7536190 7538907 |
| RefSeq identity: |
NM_003824 |
| Classification: |
Death effector domain containing Ripoptosome Death inducing signaling complex |
| Havana BLAST/BLAT: |
OTTHUMG00000167264 |
| Locus Specific Databases: |
LRG_228 |