| Long name: |
Cy5, 5 Conjugated, GATA2 (Ser401) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
GATA2 Ser401 |
| Specificity: |
This is a highly specific antibody against GATA2 Ser401 |
| Modification: |
Phosphorylation |
| Modification site: |
Ser401 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human GATA2 around the phosphorylation site of Ser401 |
| Gene ID number: |
2624 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
AGATCTTA, Although expression patterns of the various GATA transcription factors may overlap, Both GATA-4 and GATA-6 are found in heart, GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes, GATA-2 is expressed in embryonic brain and liver, GATA-3 is highly expressed in T lymphocytes, GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors, GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart, HeLa and endothelial cells, It is an essential component in the generation of the erythroid lineage, Studies with a modified GATA consensus sequence, This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1, as well as in erythroid cells, but not GATA-4 expression, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites, lung and liver tissues exhibit GATA-6, pancreas and ovary, Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Synonyms: |
NFE1B |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
GATA2 (Ser401) Conjugated |
| Short name: |
Conjugated, GATA2 (Ser401) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, 5 coupled, GATA binding protein 2 (Ser401) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
C2H2 zinc finger domain binding, DCML and IMD21 and MONOMAC and NFE1B, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006909 and pha this GO cytosis and biological process this GO :0007596 and blood coagulation and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0021514 and ventral spinal cord interneuron differentiation and biological process this GO :0021533 and cell differentiation in hindbrain and biological process this GO :0021902 and commitment of neuronal cell to specific neuron type in forebrain and biological process this GO :0021954 and central nervous system neuron development and biological process this GO :0021983 and pituitary gland development and biological process this GO :0030154 and cell differentiation and biological process this GO :0030182 and neuron differentiation and biological process this GO :0035019 and somatic stem cell maintenance and biological process this GO :0035065 and regulation of histone acetylation and biological process this GO :0035854 and eosinophil fate commitment and biological process this GO :0042472 and inner ear morphogenesis and biological process this GO :0043234 and protein complex and cellular component this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045599 and negative regulation of fat cell differentiation and biological process this GO :0045638 and negative regulation of myeloid cell differentiation and biological process this GO :0045648 and positive regulation of erythrocyte differentiation and biological process this GO :0045650 and negative regulation of macrophage differentiation and biological process this GO :0045654 and positive regulation of megakaryocyte differentiation and biological process this GO :0045746 and negative regulation of Notch signaling pathway and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048469 and cell maturation and biological process this GO :0048663 and neuron fate commitment and biological process this GO :0048873 and homeostasis of number of cells within a tissue and biological process this GO :0050766 and positive regulation of pha this GO cytosis and biological process this GO :0060216 and definitive hemopoiesis and biological process this GO :0060872 and semicircular canal development and biological process this GO :0070345 and negative regulation of fat cell proliferation and biological process this GO :0070742 and C2H2 zinc finger domain binding and molecular function this GO :0097154 and GABAergic neuron differentiation and biological process this GO :2000178 and negative regulation of neural precursor cell proliferation and biological process this GO :2000977 and regulation of forebrain neuron differentiation and biological process, GATA2 and IDBG-55213 and ENSG00000179348 and 2624, GATA2 and IDBG-646502 and ENSBTAG00000019707 and 506809, Gata2 and IDBG-166776 and ENSMUSG00000015053 and 14461, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000980 and RNA polymerase II distal enhancer sequence-specific DNA binding and molecular function this GO :0001077 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0001158 and enhancer sequence-specific DNA binding and molecular function this GO :0001655 and urogenital system development and biological process this GO :0001709 and cell fate determination and biological process this GO :0001892 and embryonic placenta development and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0006351 and transcription, this GO :0000980 : RNA polymerase II distal enhancer sequence-specific DNA binding, this GO :0000980 : RNA polymerase II distal enhancer sequence-specific DNA binding and also this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and also this GO :0001158 : enhancer sequence-specific DNA binding and also this GO :0003677 : DNA binding and also this GO :0003682 : chromatin binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0008270 : zinc ion binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0070742 : C2H2 zinc finger domain binding, this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, this GO :0001158 : enhancer sequence-specific DNA binding, this GO :0003677 : DNA binding, this GO :0003682 : chromatin binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0008270 : zinc ion binding, this GO :0043565 : sequence-specific DNA binding, this GO :0070742 : C2H2 zinc finger domain binding, GATA binding protein 2 |
| Identity: |
4171 |
| Gene: |
GATA2 |
More about : GATA2 |
| Long gene name: |
GATA binding protein 2 |
| Synonyms gene name: |
GATA-binding protein 2 |
| Locus: |
3q21, 3 |
| Discovery year: |
1992-11-03 |
| GenBank acession: |
AF169253 |
| Entrez gene record: |
2624 |
| Pubmed identfication: |
1714909 |
| RefSeq identity: |
NM_032638 |
| Classification: |
GATA zinc finger domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000159689 |
| Locus Specific Databases: |
LRG_295 |