| Long name: |
GAB3 Primary Polyclonal Antibody |
| Also known as: |
GAB3 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
GAB3 |
| Specificity: |
This is a highly specific antibody against GAB3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GAB3 |
| Gene ID number: |
139716 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, Gab1-3 contain pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins (1, Insulin receptor and EGF-receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus (6, The human Gab3 gene maps to chromosome Xq28 and encodes a 586 amino acid protein (5), The recruitment of signaling partners to Gab family members is phosphorylation dependent (1, This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes, proliferation and differentiation occur (1â, &euro, &euro, &ldquo, &ldquo, 3), 3), 4, 4), 5), 7), The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recrutiment to RTKs (1â |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
GAB3_HUMAN, GRB2-associated binder 3, GRB2-associated-binding protein 3, Growth factor receptor bound protein 2-associated protein 3, Gab3 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
GAB3 |
| Short name: |
GAB3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
GAB3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
17515 |
| Gene: |
GAB3 |
More about : GAB3 |
| Long gene name: |
GRB2 associated binding protein 3 |
| Synonyms name: |
DOS/Gab family member 3 Gab3 scaffolding protein |
| Locus: |
Xq28 |
| Discovery year: |
2002-03-05 |
| GenBank acession: |
AY057989 |
| Entrez gene record: |
139716 |
| Pubmed identfication: |
11739737 |
| RefSeq identity: |
NM_001081573 |
| Classification: |
Pleckstrin homology domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000024245 |
| Locus Specific Databases: |
Mental Retardation database |