| Long name: |
HRP Conjugated, STAT1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
HRP Conjugated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
STAT1 |
| Specificity: |
This is a highly specific antibody against STAT1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
260-310/750 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human STAT1 |
| Gene ID number: |
6772 |
| Swiss Prot: |
P42224 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Becomes activated in response to KITLG/SCF and KIT signaling, FGFR2, FGFR3 and FGFR4, Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), In response to type II IFN (IFN-gamma), It then forms a homodimer termed IFN-gamma-activated factor (GAF), May mediate cellular responses to activated FGFR1, STAT1 is tyrosine- and serine-phosphorylated, The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, cytokine KITLG/SCF and other cytokines and other growth factors, inducing a cellular antiviral state, migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2, that enters the nucleus, which drive the cell in an antiviral state, Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% Gentamicin, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
STAT91 ISGF-3 |
| Properties: |
Also monoclonal HRP conjugates are often used for Western Blot, HRP conjugates are often primary rabbit polyclonal antibodies couples to the , found in the roots of , (HRP), C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°, enzyme , horseradish, horseradish peroxidase |
| Gene target: |
STAT1 Conjugated |
| Short name: |
Conjugated, STAT1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
HRP |
| Alternative name: |
91kDa (Antibody to), horseradish peroxidase coupled, signal transducer and activator on transcription 1 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
91kDa, CANDF7 and IMD31A and IMD31B and IMD31C and ISGF-3 and STAT91, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007259 and JAK-STAT cascade and biological process this GO :0007584 and response to nutrient and biological process this GO :0008015 and blood circulation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009612 and response to mechanical stimulus and biological process this GO :0009617 and response to bacterium and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0016032 and viral process and biological process this GO :0016525 and negative regulation of angiogenesis and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019899 and enzyme binding and molecular function this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0031663 and lipopolysaccharide-mediated signaling pathway and biological process this GO :0031730 and CCR5 chemokine receptor binding and molecular function this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0033209 and tumor necrosis factor-mediated signaling pathway and biological process this GO :0034097 and response to cytokine and biological process this GO :0034240 and negative regulation of macrophage fusion and biological process this GO :0035458 and cellular response to interferon-beta and biological process this GO :0042493 and response to drug and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043124 and negative regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043330 and response to exogenous dsRNA and biological process this GO :0043434 and response to peptide hormone and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048661 and positive regulation of smooth muscle cell proliferation and biological process this GO :0051591 and response to cAMP and biological process this GO :0051607 and defense response to virus and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060334 and regulation of interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0060338 and regulation of type I interferon-mediated signaling pathway and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :0061326 and renal tubule development and biological process this GO :0072136 and metanephric mesenchymal cell proliferation involved in metanephros development and biological process this GO :0072162 and metanephric mesenchymal cell differentiation and biological process this GO :0072308 and negative regulation of metanephric nephron tubule epithelial cell differentiation and biological process, STAT1 and IDBG-642654 and ENSBTAG00000007867 and 510814, STAT1 and IDBG-77617 and ENSG00000115415 and 6772, Stat1 and IDBG-153162 and ENSMUSG00000026104 and 20846, nuclei, sequence-specific DNA binding, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000790 and nuclear chromatin and cellular component this GO :0000978 and RNA polymerase II core promoter proximal region sequence-specific DNA binding and molecular function this GO :0000979 and RNA polymerase II core promoter sequence-specific DNA binding and molecular function this GO :0000983 and RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity and molecular function this GO :0001937 and negative regulation of endothelial cell proliferation and biological process this GO :0002053 and positive regulation of mesenchymal cell proliferation and biological process this GO :0003340 and negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis and biological process this GO :0003677 and DNA binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005164 and tumor necrosis factor receptor binding and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding and also this GO :0000979 : RNA polymerase II core promoter sequence-specific DNA binding and also this GO :0000983 : RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity and also this GO :0003677 : DNA binding and also this GO :0003690 : double-stranded DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0004871 : signal transducer activity and also this GO :0005164 : tumor necrosis factor receptor binding and also this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding and also this GO :0019899 : enzyme binding and also this GO :0031730 : CCR5 chemokine receptor binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0043565 : sequence-specific DNA binding, this GO :0000979 : RNA polymerase II core promoter sequence-specific DNA binding, this GO :0000983 : RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, this GO :0003677 : DNA binding, this GO :0003690 : double-stranded DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0004871 : signal transducer activity, this GO :0005164 : tumor necrosis factor receptor binding, this GO :0005509 : calcium ion binding, this GO :0005515 : protein binding, this GO :0019899 : enzyme binding, this GO :0031730 : CCR5 chemokine receptor binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0043565 : sequence-specific DNA binding, 515988, signal transducer and activator of transcription 1 |
| Identity: |
11362 |
| Gene: |
STAT1 |
More about : STAT1 |
| Long gene name: |
signal transducer and activator of transcription 1 |
| Synonyms gene name: |
91kD signal transducer and activator of transcription 1, 91kDa , signal transducer and activator of transcription 1 |
| Synonyms name: |
transcription factor ISGF-3 components p91/p84 |
| Locus: |
2q32, 2 |
| Discovery year: |
1995-11-08 |
| Entrez gene record: |
6772 |
| Pubmed identfication: |
7885841 |
| RefSeq identity: |
NM_007315 |
| Classification: |
SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000132699 |
| Locus Specific Databases: |
STAT1base: Mutation registry for STAT1 deficiency LRG_111 |