| Long name: |
Biotin Conjugated, EPO Receptor (Tyr368) Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
EPO Receptor Tyr368 |
| Specificity: |
This is a highly specific antibody against EPO Receptor Tyr368 |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr368 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human EPO Receptor around the phosphorylation site of Tyr368 |
| Gene ID number: |
2057 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
A functional EPOR is found in the cardiovascular system, Defects in the EPOR may produce erythroleukemia and familial erythrocytosis, EPOR-S (soluble form), In animal studies, The stimulated EPOR appears to have a role in erythroid cell survival, There are several isoforms including: EPOR-F (full length), Upon erythropoietin (EPO) binding, and EPOR-T (truncated form), and data suggest that the EPO/EPO receptor system plays an important role in cardiac function, including endothelial cells and cardiomyocytes, phosphatidylinositol 3-kinase and STAT transcription factors, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis, The erythropoietin receptor (EPOR) is a member of the cytokine receptor family |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
EP |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
EPO Receptor (Tyr368) Conjugated |
| Short name: |
Conjugated, EPO Receptor (Tyr368) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, erythropoietin Receptor (Tyr368) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0046579 and positive regulation of Ras protein signal transduction and biological process this GO :0048678 and response to axon injury and biological process this GO :0051602 and response to electrical stimulus and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0061418 and regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0070555 and response to interleukin-1 and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0071474 and cellular hyperosmotic response and biological process this GO :1902219 and negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress and biological process this GO :1902251 and negative regulation of erythrocyte apoptotic process and biological process this GO :2001258 and negative regulation of cation channel activity and biological process, EP and MVCD2, EPO and IDBG-31941 and ENSG00000130427 and 2056, EPO and IDBG-640493 and ENSBTAG00000003430 and 280784, Epo and IDBG-205003 and ENSMUSG00000029711 and 13856, Extracellular, protein kinase activator activity, this GO :0001666 and response to hypoxia and biological process this GO :0005128 and erythropoietin receptor binding and molecular function this GO :0005179 and hormone activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007566 and embryo implantation and biological process this GO :0007568 and aging and biological process this GO :0007584 and response to nutrient and biological process this GO :0008015 and blood circulation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009651 and response to salt stress and biological process this GO :0009986 and cell surface and cellular component this GO :0010523 and negative regulation of calcium ion transport into cytosol and biological process this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0030218 and erythrocyte differentiation and biological process this GO :0030295 and protein kinase activator activity and molecular function this GO :0032496 and response to lipopolysaccharide and biological process this GO :0033033 and negative regulation of myeloid cell apoptotic process and biological process this GO :0033189 and response to vitamin A and biological process this GO :0033574 and response to testosterone and biological process this GO :0042523 and positive regulation of tyrosine phosphorylation of Stat5 protein and biological process this GO :0042541 and hemoglobin biosynthetic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043249 and erythrocyte maturation and biological process this GO :0043627 and response to estrogen and biological process this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0045740 and positive regulation of DNA replication and biological process this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0045893 and positive regulation of transcription, this GO :0005128 : erythropoietin receptor binding, this GO :0005128 : erythropoietin receptor binding and also this GO :0005179 : hormone activity and also this GO :0005515 : protein binding and also this GO :0030295 : protein kinase activator activity, this GO :0005179 : hormone activity, this GO :0005515 : protein binding, this GO :0030295 : protein kinase activator activity, erythropoietin |
| Identity: |
3415 |
| Gene: |
EPO |
More about : EPO |
| Long gene name: |
erythropoietin |
| Locus: |
7q22, 1 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
X02157 |
| Entrez gene record: |
2056 |
| Pubmed identfication: |
9799793 3838366 |
| RefSeq identity: |
NM_000799 |
| Classification: |
Endogenous ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000152121 |