| Long name: |
ALEXA FLUOR 350 Conjugated, PARK7 Polyclonal Antibody |
| Also known as: |
Anti-PARK7 PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PARK7 |
| Specificity: |
This is a highly specific antibody against PARK7 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
130-189/189 |
| Subcellular location: |
Cell membrane, Mitochondrion, Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PARK7 |
| Gene ID Number: |
11315 |
| Swiss Prot: |
Q99497 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts on early glycation intermediates (hemithioacetals and aminocarbinols), Deglycates cysteines, Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825), It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, Its involvement in protein repair could also explain other unrelated functions, Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745), Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease, PubMed:12796482, PubMed:14749723, PubMed:15502874, PubMed:16632486), PubMed:17015834, PubMed:18711745, PubMed:18711745), PubMed:19229105, PubMed:20304780, PubMed:21097510, PubMed:25416785), Regulates astrocyte inflammatory responses, Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, and releases repaired proteins and lactate or glycolate, and thus reactivates these proteins by reversing glycation by glyoxals, arginines and lysines residues in proteins, for instance, functions probably related to its primary function (PubMed:17015834, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046), preventing the formation of advanced glycation endproducts (AGE) (PubMed:25416785), respectively, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
DJ-1 DJ1 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
PARK7 |
| Short name: |
PARK7 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, PARK7 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16369 |
| Gene: |
PARK7 |
More about : PARK7 |
| Long gene name: |
Parkinsonism associated deglycase |
| Synonyms gene name: |
Parkinson disease (autosomal recessive, early onset) 7 parkinson protein 7 |
| Locus: |
1p36, 23 |
| Discovery year: |
2001-08-07 |
| GenBank acession: |
D61380 |
| Entrez gene record: |
11315 |
| Pubmed identfication: |
11462174 9070310 25416785 |
| RefSeq identity: |
NM_007262 |
| Classification: |
Parkinson disease associated genes |
| Havana BLAST/BLAT: |
OTTHUMG00000001210 |
| Locus Specific Databases: |
Parkinson', s disease Mutation Database |