| Long name: |
ALEXA FLUOR 350 Conjugated, DMC1 Polyclonal Antibody |
| Also known as: |
Anti-DMC1 PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
DMC1 |
| Specificity: |
This is a highly specific antibody against DMC1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DMC1 |
| Gene ID Number: |
11144 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Additional proteins involved in the pathway include Nibrin and Dmc1, An alternative spliced form of Dmc1, Dmc1 is specifically involved in meiotic recombination, Nibrin, Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination, Rad51 is essential for mitotic and meiotic recombination, Rad52 is thought to be involved in an early stage of Rad51-mediated recombination, The DNA repair proteins Rad51 and Rad52 are key components of the double-strand-break repair (DSBR) pathway, The alternatively spliced Dmc1-D transcript is detected in both male and female germ cells, and its mutation in yeast and mammalian cells results in chromosome loss, designated Dmc1-D, indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis, is absent in Nijemegen breakage syndrome (NBS) patients, is deleted for a region between the two motifs involved in nucleotide binding, which complexes with Mre11 and Rad50, DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
LIM15 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
DMC1 |
| Short name: |
DMC1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, DMC1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2927 |
| Gene: |
DMC1 |
More about : DMC1 |
| Long gene name: |
DNA meiotic recombinase 1 |
| Synonyms gene name: |
DMC1 (dosage suppressor of mck1, meiosis-specific homologous recombination (yeast) , yeast homolog) meiosis-specific homologous recombination DMC1 dosage suppressor of mck1 homolog |
| Locus: |
22q13, 1 |
| Discovery year: |
1999-10-29 |
| GenBank acession: |
D63882 |
| Entrez gene record: |
11144 |
| Pubmed identfication: |
8602360 8590282 17541404 |
| RefSeq identity: |
NM_007068 |
| Havana BLAST/BLAT: |
OTTHUMG00000151088 |