| Long name: |
ALEXA FLUOR 594 Conjugated, BNIP3 (Ser95) Polyclonal Antibody |
| Also known as: |
Anti-BNIP3 Ser95 PAb ALEXA FLUOR 594 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
BNIP3 Ser95 |
| Specificity: |
This is a highly specific antibody against BNIP3 Ser95 |
| Modification: |
Phosphorylation |
| Modification Site: |
Ser95 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human BNIP3 around the phosphorylation site of Ser95 |
| Gene ID Number: |
664 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
(previously designated Nip2 and Nip21 in human and mouse respectively), A family of interacting proteins, BNIP-1 contains a hydrophobic transmembrane domain, BNIP-2, BNIP-2, BNIP-2 enhances the GTPase activity of Cdc42GAP, BNIP-3 and Nix, BNIP-3 preferentially binds to Bcl-xL and induces apoptosis by suppressing the anti-apoptosis activity of Bcl-xL, Nix, Through binding to Cdc42GAP, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins, associate with both the E1B protein and Bcl-2 proteins to mediate apoptotic signaling, endoplasmic recticulum and mitochondria, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, is highly related to BNIP-3, mediating the signaling pathways involving receptor kinases, shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP), small GTPases and apoptotic proteins, which are designated Nip or Bnip and include BNIP-1, which enables its localization to the nuclear envelope, which is also designated Nip3L or Bnip3L, The adenovirus E1B protein is a viral homolog of the Bcl-2 family of proteins that are involved in regulating cell death |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Nip3 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
594, ALEXA FLUOR®, Alexa Fluor |
| Conjugated: |
Alexa conjugate 1 |
| Gene target: |
BNIP3 (Ser95) |
| Short name: |
BNIP3 (Ser95) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 594 |
| Alternative name: |
ALEXA FLUOR 594, B-cell CLL/lymphoma 2/adenovirus E1B 19kDa interacting protein 3 (Ser95) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BNIP3 and IDBG-641206 and ENSBTAG00000017804 and 615342, BNIP3 and IDBG-93314 and ENSG00000176171 and 664, Bnip3 and IDBG-269444 and ENSMUSG00000078566 and 12176, GTPase binding, NIP3, nuclei, this GO :0001666 and response to hypoxia and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005635 and nuclear envelope and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005740 and mitochondrial envelope and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0006915 and apoptotic process and biological process this GO :0008219 and cell death and biological process this GO :0008626 and granzyme-mediated apoptotic signaling pathway and biological process this GO :0010508 and positive regulation of autophagy and biological process this GO :0010637 and negative regulation of mitochondrial fusion and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0030425 and dendrite and cellular component this GO :0031307 and integral component of mitochondrial outer membrane and cellular component this GO :0031966 and mitochondrial membrane and cellular component this GO :0035694 and mitochondrial protein catabolic process and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043068 and positive regulation of programmed cell death and biological process this GO :0043243 and positive regulation of protein complex disassembly and biological process this GO :0043653 and mitochondrial fragmentation involved in apoptotic process and biological process this GO :0045837 and negative regulation of membrane potential and biological process this GO :0046902 and regulation of mitochondrial membrane permeability and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048102 and autophagic cell death and biological process this GO :0050873 and brown fat cell differentiation and biological process this GO :0051020 and GTPase binding and molecular function this GO :0051402 and neuron apoptotic process and biological process this GO :0051607 and defense response to virus and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0070301 and cellular response to hydrogen peroxide and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071279 and cellular response to cobalt ion and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0072593 and reactive oxygen species metabolic process and biological process this GO :0090141 and positive regulation of mitochondrial fission and biological process this GO :0090200 and positive regulation of release of cytochrome c from mitochondria and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :0097345 and mitochondrial outer membrane permeabilization and biological process this GO :1990144 and intrinsic apoptotic signaling pathway in response to hypoxia and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0046982 : protein heterodimerization activity and also this GO :0051020 : GTPase binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0046982 : protein heterodimerization activity, this GO :0051020 : GTPase binding, BCL2/adenovirus E1B 19kDa interacting protein 3 |
| Identity: |
1084 |
| Gene: |
BNIP3 |
More about : BNIP3 |
| Long gene name: |
BCL2 interacting protein 3 |
| Synonyms gene name: |
BCL2/adenovirus E1B 19kDa interacting protein 3 |
| Locus: |
10q26, 3 |
| Discovery year: |
1997-03-19 |
| GenBank acession: |
U15174 |
| Entrez gene record: |
664 |
| Pubmed identfication: |
7954800 |
| Classification: |
BCL2 homology region 3 (BH3) only |
| Havana BLAST/BLAT: |
OTTHUMG00000019278 |