| Long name: |
BCAR1 (Tyr249) Primary Polyclonal Antibody |
| Also known as: |
BCAR1 (Tyr249) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
BCAR1 Tyr249 |
| Specificity: |
This is a highly specific antibody against BCAR1 Tyr249 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Tyr249 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human BCAR1 around the phosphorylation site of Tyr249 |
| Gene ID number: |
9564 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
By immunoprecipitation analysis, One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk, p130 Cas (for Crk-associated substrate) exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins, suggesting a role in v-Crk-mediated cell signaling, which in turn phosphorylates p130 Cas, p130 represents one of several known substrates for v-Crk encoded p47 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BCAR 1, BCAR1_HUMAN, BCAR1phospho Y249, Bcar1, Breast cancer anti estrogen resistance 1, Breast cancer anti estrogen resistance 1 protein, Breast cancer anti-estrogen resistance protein 1, CAS, CRK-associated substrate, CRKAS, Cas scaffolding protein family member 1, Crk associated substrate, Crk associated substrate p130Cas, P130CAS, p-BCAR1p-Tyr249, BCAR1 phospho Y249 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
BCAR1 (Tyr249) |
| Short name: |
BCAR1 (Tyr249) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
breast cancer antibody to-estrogen resistance 1 (Tyr249) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BCAR1 and IDBG-42468 and ENSG00000050820 and 9564, BCAR1 and IDBG-629067 and ENSBTAG00000012002 and, Bcar1 and IDBG-193577 and ENSMUSG00000031955 and 12927, CAS and CAS1 and CASS1 and CRKAS and P130Cas, nuclei, protein kinase binding, this GO :0001558 and regulation of cell growth and biological process this GO :0001726 and ruffle and cellular component this GO :0004871 and signal transducer activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0007015 and actin filament organization and biological process this GO :0007155 and cell adhesion and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007596 and blood coagulation and biological process this GO :0008283 and cell proliferation and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0010595 and positive regulation of endothelial cell migration and biological process this GO :0016477 and cell migration and biological process this GO :0017124 and SH3 domain binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030027 and lamellipodium and cellular component this GO :0030168 and platelet activation and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0035729 and cellular response to hepatocyte growth factor stimulus and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0048008 and platelet-derived growth factor receptor signaling pathway and biological process this GO :0048010 and vascular endothelial growth factor receptor signaling pathway and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048012 and hepatocyte growth factor receptor signaling pathway and biological process this GO :0050851 and antigen receptor-mediated signaling pathway and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050853 and B cell receptor signaling pathway and biological process this GO :0051301 and cell division and biological process this GO :0060326 and cell chemotaxis and biological process, this GO :0004871 : signal transducer activity, this GO :0004871 : signal transducer activity and also this GO :0005515 : protein binding and also this GO :0017124 : SH3 domain binding and also this GO :0019901 : protein kinase binding, this GO :0005515 : protein binding, this GO :0017124 : SH3 domain binding, this GO :0019901 : protein kinase binding, breast cancer anti-estrogen resistance 1 |
| Identity: |
971 |
| Gene: |
BCAR1 |
More about : BCAR1 |
| Long gene name: |
BCAR1, Cas family scaffolding protein |
| Synonyms gene name: |
breast cancer anti-estrogen resistance 1 |
| Synonyms: |
P130Cas Crkas CAS CASS1 |
| Synonyms name: |
Crk-associated substrate Cas scaffolding protein family member 1 |
| Locus: |
16q23, 1 |
| Discovery year: |
1999-04-29 |
| GenBank acession: |
AJ242987 |
| Entrez gene record: |
9564 |
| Pubmed identfication: |
8413311 10639512 |
| RefSeq identity: |
NM_014567 |
| Classification: |
Cas scaffolding proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000137604 |