ATF2 (Thr55) Antibody

Catalog number:	bs-12539R Buy Now
Price:	602 €
Supplier:	genways
Product name:	ATF2 (Thr55) Antibody
Quantity:	1 x 1 vial
Other quantities:	0.1ml 263€
Related search:	atf antibody protein factor binding neurotrophic

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Long name:	ATF2 (Thr55) Primary Polyclonal Antibody
Also known as:	ATF2 (Thr55) PAb
Category:	Primary Antibodies
Conjugation:	Unconjugated
Target Antigen:	ATF2 Thr55
Specificity:	This is a highly specific antibody against ATF2 Thr55
Modification(s):	Phosphorylation
Modification site(s):	Thr55
Clonality:	Polyclonal antibody
Clone number:	Polyclonal antibody
Concentration:	1ug per 1ul
Source:	KLH conjugated synthetic phosphopeptide derived from mouse ATF2 around the phosphorylation site of Thr55
Gene ID number:	11909
Tested Applications:	IF(IHC-P), IHC-P, WB
Recommended dilutions:	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity:	Mouse, Rat, Human
Cross reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen:	ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families, ATF2 is abundantly expressed in brain, Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, It is a stronger activator as a heterodimer with cJun than as a homodimer, Many of these genes are important in cell growth and differentiation, Several isoforms of ATF2 arise by differential splicing, Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain, This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase, and UV irradiation, and in stress and immune responses, inflammatory cytokines, seemingly in a protein phosphatase-dependent mechanism, ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names:	ATF 2, ATF2 protein, Activating Transcription Factor 2, Atf-2, CREB 2, HB 16, cAMP Response Element Binding Protein 2, cAMP response element binding protein CRE BP1, cAMP-dependent transcription factor ATF-2, p-ATF2 phospho T55, p-ATF2 phospho T73 + T55, ATF2 phospho T55
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target:	ATF2 (Thr55)
Short name:	ATF2 (Thr55) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Alternative name:	ATF2 (Thr55) (Antibody to)
Alternative technique:	antibodies
Identity:	4232
Gene:	GDNF | More about : GDNF
Long gene name:	glial cell derived neurotrophic factor
Synonyms:	ATF1 ATF2 HFB1-GDNF
Synonyms name:	astrocyte-derived trophic factor glial cell line derived neurotrophic factor glial derived neurotrophic factor
Locus:	5p13, 2
Discovery year:	1995-05-04
Entrez gene record:	2668
Pubmed identfication:	8493557
RefSeq identity:	NM_000514
Classification:	Endogenous ligands
Havana BLAST/BLAT:	OTTHUMG00000090809

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• #antibody
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• #neurotrophic