| Long name: |
ALEXA FLUOR 594 Conjugated, ACVR2B/ACTR-IIB Polyclonal Antibody |
| Also known as: |
Anti-ACVR2B/ACTR-IIB PAb ALEXA FLUOR 594 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
ACVR2B/ACTR-IIB |
| Specificity: |
This is a highly specific antibody against ACVR2B/ACTR-IIB |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
50-100/512 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ACVR2B/ACTR-IIB |
| Gene ID Number: |
93 |
| Swiss Prot: |
Q13705 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
ACVR1B or ACVR1c), Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase, Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary, Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor, FSH production by the pituitary gland, Inhibitory SMAD7, Once activated, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4, Soon after their association with the activin receptor and subsequent phosphorylation, The activated receptor type-2 then phosphorylates and activates the type-1 receptor, The type-1 receptors like ACVR1B act as downstream transducers of activin signals, This SMAD complex translocates into the nucleus where it mediates activin-induced transcription, Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, Within the receptor complex, activin-B/INHBB as well as inhibin-A/INHA-INHBA), can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, extracellular matrix production, hair follicle development and cycling, immunosuppression and carcinogenesis, on serine residues of the C-terminal tail, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, thereby blocking the activin signal, which is recruited to ACVR1B through FKBP1A, wound healing, Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1 |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ActR-IIB |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
594, ALEXA FLUOR®, Alexa Fluor |
| Conjugated: |
Alexa conjugate 1 |
| Gene target: |
ACVR2B/ACTR-IIB |
| Short name: |
ACVR2B/ACTR-IIB Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 594 |
| Alternative name: |
ALEXA FLUOR 594, ACVR2B/ACTR-IIB (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
174 |
| Gene: |
ACVR2B |
More about : ACVR2B |
| Long gene name: |
activin A receptor type 2B |
| Synonyms gene name: |
activin A receptor, type IIB |
| Locus: |
3p22, 2 |
| Discovery year: |
1997-03-19 |
| GenBank acession: |
X77533 |
| Entrez gene record: |
93 |
| Pubmed identfication: |
8161782 9621519 |
| RefSeq identity: |
NM_001106 |
| Classification: |
Type 2 receptor serine/threonine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000131291 |